Longitudinal Assessment of Systemic and Genital Tract Inflammatory Markers and Endogenous Genital Tract E. coli Inhibitory Activity in HIV-Infected and Uninfected Women

Marla J. Keller, Aileen P. McGinn, Yungtai Lo, Ashley Huber, Lilia Espinoza, Howard Minkoff, Christine Colie, Marek J. Nowicki, Gypsyamber D'Souza, Kathryn Anastos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Problem: Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study: Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women's Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results: There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion: HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.

Original languageEnglish (US)
JournalAmerican Journal of Reproductive Immunology
DOIs
StateAccepted/In press - 2016

Fingerprint

Therapeutic Irrigation
HIV
Escherichia coli
Bacterial Vaginosis
Inflammation
Mucosal Immunity
CD4 Lymphocyte Count
Viral Load
Health
Therapeutics

Keywords

  • Bacterial vaginosis
  • Genital tract
  • HIV
  • Inflammation
  • Mucosal immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

@article{0136826932cb452a9450ab50506be3a7,
title = "Longitudinal Assessment of Systemic and Genital Tract Inflammatory Markers and Endogenous Genital Tract E. coli Inhibitory Activity in HIV-Infected and Uninfected Women",
abstract = "Problem: Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study: Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women's Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results: There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion: HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.",
keywords = "Bacterial vaginosis, Genital tract, HIV, Inflammation, Mucosal immunity",
author = "Keller, {Marla J.} and McGinn, {Aileen P.} and Yungtai Lo and Ashley Huber and Lilia Espinoza and Howard Minkoff and Christine Colie and Nowicki, {Marek J.} and Gypsyamber D'Souza and Kathryn Anastos",
year = "2016",
doi = "10.1111/aji.12518",
language = "English (US)",
journal = "American Journal of Reproductive Immunology and Microbiology",
issn = "1046-7408",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Longitudinal Assessment of Systemic and Genital Tract Inflammatory Markers and Endogenous Genital Tract E. coli Inhibitory Activity in HIV-Infected and Uninfected Women

AU - Keller, Marla J.

AU - McGinn, Aileen P.

AU - Lo, Yungtai

AU - Huber, Ashley

AU - Espinoza, Lilia

AU - Minkoff, Howard

AU - Colie, Christine

AU - Nowicki, Marek J.

AU - D'Souza, Gypsyamber

AU - Anastos, Kathryn

PY - 2016

Y1 - 2016

N2 - Problem: Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study: Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women's Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results: There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion: HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.

AB - Problem: Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study: Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women's Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results: There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion: HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.

KW - Bacterial vaginosis

KW - Genital tract

KW - HIV

KW - Inflammation

KW - Mucosal immunity

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