Longitudinal assessment of systemic and genital tract inflammatory markers and endogenous genital tract E. Coli inhibitory activity in HIV-infected and uninfected women

Marla J. Keller, Aileen P. McGinn, Yungtai Lo, Ashley Huber, Lilia Espinoza, Howard Minkoff, Christine Colie, Marek J. Nowicki, Gypsyamber D’Souza, Kathryn Anastos

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Problem Stability over time of systemic and mucosal immunity and their associations with bacterial vaginosis (BV) and HIV-specific parameters were assessed. Method of Study Immune mediators and HIV viral load in plasma and cervicovaginal lavage (CVL), E. coli inhibition, and Nugent score were measured at three semiannual visits among 94 participants in the Women’s Interagency HIV Study. Mixed models identified the factors associated with immune mediators. Results There was higher E. coli inhibition and lower inflammation over time in the genital tract and systemically. BV was consistently associated with higher CVL inflammatory mediators and lower CVL E. coli inhibition. HIV-infected women with higher CD4 counts had lower systemic and genital inflammatory mediators, and genital HIV shedding was associated with higher CVL inflammatory mediators. Use of antiretroviral therapy (ART) was associated with lower plasma and CVL mediators, but higher E. coli inhibition. Conclusion HIV and BV are linked to inflammation, and ART may be associated with improved vaginal health.

Original languageEnglish (US)
Pages (from-to)631-642
Number of pages12
JournalAmerican Journal of Reproductive Immunology
Volume75
Issue number6
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Bacterial vaginosis
  • Genital tract
  • HIV
  • Inflammation
  • Mucosal immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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