Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen

Phillip M. Pierorazio, Thomas J. Guzzo, Misop Han, Trinity J. Bivalacqua, Jonathan I. Epstein, Edward M. Schaeffer, Mark P. Schoenberg, Patrick C. Walsh, Alan W. Partin

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Abstract

Objectives: To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort. Methods: The institutional RP database was queried. A total of 9381 patients with complete follow-up underwent RP from 1982 to 2008. Of these 9381 patients, 1061 had pathologic Gleason sum 8-10 cancer. The patient and prostate cancer characteristics were evaluated. Survival analyses were performed using the Kaplan-Meier method. Univariate and multivariate proportional hazard regression models were created to evaluate the pertinent predictors of CSS (death from, or attributed to, prostate cancer). Results: The median preoperative prostate-specific antigen level was 7.6 ng/mL; 435 men had clinical Stage T1 tumor, 568 had Stage T2, and 36 had Stage T3. The biopsy Gleason sum was <7, 7, and >7 in 244 (22.3%), 406 (37.2%), and 425 (38.9%) patients, respectively. The median follow-up was 5 years (range 1-23). The actuarial 15-year recurrence-free survival, CSS, and overall survival rate was 20.7%, 57.4%, and 45.4%, respectively. On multivariate analysis, the predictors of poor CSS were pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement. Patients with pathologic Gleason sum 8 and organ-confined disease had a CSS rate of 89.9% at 15 years. Conclusions: The results of our study have shown that 80% of the men with Gleason sum 8-10 who undergo RP will have experienced biochemical recurrence by 15 years. However, the CSS rate approached 90% for men with pathologic organ-confined disease. Higher pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement were independent predictors of worse CSS.

Original languageEnglish (US)
Pages (from-to)715-721
Number of pages7
JournalUrology
Volume76
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

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Prostatectomy
Survival
Neoplasms
Prostatic Neoplasms
Survival Rate
Seminal Vesicles
Lymph Nodes
Recurrence
Prostate-Specific Antigen
Survival Analysis
Proportional Hazards Models
Multivariate Analysis
Databases
Biopsy

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Pierorazio, P. M., Guzzo, T. J., Han, M., Bivalacqua, T. J., Epstein, J. I., Schaeffer, E. M., ... Partin, A. W. (2010). Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen. Urology, 76(3), 715-721. https://doi.org/10.1016/j.urology.2009.11.085

Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen. / Pierorazio, Phillip M.; Guzzo, Thomas J.; Han, Misop; Bivalacqua, Trinity J.; Epstein, Jonathan I.; Schaeffer, Edward M.; Schoenberg, Mark P.; Walsh, Patrick C.; Partin, Alan W.

In: Urology, Vol. 76, No. 3, 09.2010, p. 715-721.

Research output: Contribution to journalArticle

Pierorazio, PM, Guzzo, TJ, Han, M, Bivalacqua, TJ, Epstein, JI, Schaeffer, EM, Schoenberg, MP, Walsh, PC & Partin, AW 2010, 'Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen', Urology, vol. 76, no. 3, pp. 715-721. https://doi.org/10.1016/j.urology.2009.11.085
Pierorazio PM, Guzzo TJ, Han M, Bivalacqua TJ, Epstein JI, Schaeffer EM et al. Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen. Urology. 2010 Sep;76(3):715-721. https://doi.org/10.1016/j.urology.2009.11.085
Pierorazio, Phillip M. ; Guzzo, Thomas J. ; Han, Misop ; Bivalacqua, Trinity J. ; Epstein, Jonathan I. ; Schaeffer, Edward M. ; Schoenberg, Mark P. ; Walsh, Patrick C. ; Partin, Alan W. / Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen. In: Urology. 2010 ; Vol. 76, No. 3. pp. 715-721.
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abstract = "Objectives: To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort. Methods: The institutional RP database was queried. A total of 9381 patients with complete follow-up underwent RP from 1982 to 2008. Of these 9381 patients, 1061 had pathologic Gleason sum 8-10 cancer. The patient and prostate cancer characteristics were evaluated. Survival analyses were performed using the Kaplan-Meier method. Univariate and multivariate proportional hazard regression models were created to evaluate the pertinent predictors of CSS (death from, or attributed to, prostate cancer). Results: The median preoperative prostate-specific antigen level was 7.6 ng/mL; 435 men had clinical Stage T1 tumor, 568 had Stage T2, and 36 had Stage T3. The biopsy Gleason sum was <7, 7, and >7 in 244 (22.3{\%}), 406 (37.2{\%}), and 425 (38.9{\%}) patients, respectively. The median follow-up was 5 years (range 1-23). The actuarial 15-year recurrence-free survival, CSS, and overall survival rate was 20.7{\%}, 57.4{\%}, and 45.4{\%}, respectively. On multivariate analysis, the predictors of poor CSS were pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement. Patients with pathologic Gleason sum 8 and organ-confined disease had a CSS rate of 89.9{\%} at 15 years. Conclusions: The results of our study have shown that 80{\%} of the men with Gleason sum 8-10 who undergo RP will have experienced biochemical recurrence by 15 years. However, the CSS rate approached 90{\%} for men with pathologic organ-confined disease. Higher pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement were independent predictors of worse CSS.",
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T1 - Long-term survival after radical prostatectomy for men with high gleason sum in pathologic specimen

AU - Pierorazio, Phillip M.

AU - Guzzo, Thomas J.

AU - Han, Misop

AU - Bivalacqua, Trinity J.

AU - Epstein, Jonathan I.

AU - Schaeffer, Edward M.

AU - Schoenberg, Mark P.

AU - Walsh, Patrick C.

AU - Partin, Alan W.

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N2 - Objectives: To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort. Methods: The institutional RP database was queried. A total of 9381 patients with complete follow-up underwent RP from 1982 to 2008. Of these 9381 patients, 1061 had pathologic Gleason sum 8-10 cancer. The patient and prostate cancer characteristics were evaluated. Survival analyses were performed using the Kaplan-Meier method. Univariate and multivariate proportional hazard regression models were created to evaluate the pertinent predictors of CSS (death from, or attributed to, prostate cancer). Results: The median preoperative prostate-specific antigen level was 7.6 ng/mL; 435 men had clinical Stage T1 tumor, 568 had Stage T2, and 36 had Stage T3. The biopsy Gleason sum was <7, 7, and >7 in 244 (22.3%), 406 (37.2%), and 425 (38.9%) patients, respectively. The median follow-up was 5 years (range 1-23). The actuarial 15-year recurrence-free survival, CSS, and overall survival rate was 20.7%, 57.4%, and 45.4%, respectively. On multivariate analysis, the predictors of poor CSS were pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement. Patients with pathologic Gleason sum 8 and organ-confined disease had a CSS rate of 89.9% at 15 years. Conclusions: The results of our study have shown that 80% of the men with Gleason sum 8-10 who undergo RP will have experienced biochemical recurrence by 15 years. However, the CSS rate approached 90% for men with pathologic organ-confined disease. Higher pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement were independent predictors of worse CSS.

AB - Objectives: To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort. Methods: The institutional RP database was queried. A total of 9381 patients with complete follow-up underwent RP from 1982 to 2008. Of these 9381 patients, 1061 had pathologic Gleason sum 8-10 cancer. The patient and prostate cancer characteristics were evaluated. Survival analyses were performed using the Kaplan-Meier method. Univariate and multivariate proportional hazard regression models were created to evaluate the pertinent predictors of CSS (death from, or attributed to, prostate cancer). Results: The median preoperative prostate-specific antigen level was 7.6 ng/mL; 435 men had clinical Stage T1 tumor, 568 had Stage T2, and 36 had Stage T3. The biopsy Gleason sum was <7, 7, and >7 in 244 (22.3%), 406 (37.2%), and 425 (38.9%) patients, respectively. The median follow-up was 5 years (range 1-23). The actuarial 15-year recurrence-free survival, CSS, and overall survival rate was 20.7%, 57.4%, and 45.4%, respectively. On multivariate analysis, the predictors of poor CSS were pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement. Patients with pathologic Gleason sum 8 and organ-confined disease had a CSS rate of 89.9% at 15 years. Conclusions: The results of our study have shown that 80% of the men with Gleason sum 8-10 who undergo RP will have experienced biochemical recurrence by 15 years. However, the CSS rate approached 90% for men with pathologic organ-confined disease. Higher pathologic Gleason sum 9-10 and seminal vesicle and lymph node involvement were independent predictors of worse CSS.

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