Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

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Abstract

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

Original languageEnglish (US)
Pages (from-to)1196-1203
Number of pages8
JournalInfection and Immunity
Volume73
Issue number2
DOIs
Publication statusPublished - Feb 1 2005

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