Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

Vasan K. Sambandamurthy, Steven C. Derrick, Kripa V. Jalapathy, Bing Chen, Robert G. Russell, Sheldon L. Morris, William R. Jacobs

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

Original languageEnglish (US)
Pages (from-to)1196-1203
Number of pages8
JournalInfection and immunity
Volume73
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis'. Together they form a unique fingerprint.

Cite this