Long-term plasticity of neurotransmitter release: Emerging mechanisms and contributions to brain function and disease

Hannah R. Monday, Thomas J. Younts, Pablo E. Castillo

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Long-lasting changes of brain function in response to experience rely on diverse forms of activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long-term depression of neurotransmitter release, which are widely expressed by excitatory and inhibitory synapses throughout the central nervous system and can dynamically regulate information flow in neural circuits. This review article explores recent advances in presynaptic long-term plasticity mechanisms and contributions to circuit function. Growing evidence indicates that presynaptic plasticity may involve structural changes, presynaptic protein synthesis, and transsynaptic signaling. Presynaptic long-term plasticity can alter the short-term dynamics of neurotransmitter release, thereby contributing to circuit computations such as novelty detection, modifications of the excitatory/inhibitory balance, and sensory adaptation. In addition, presynaptic long-term plasticity underlies forms of learning and its dysregulation participates in several neuropsychiatric conditions, including schizophrenia, autism, intellectual disabilities, neurodegenerative diseases, and drug abuse.

Original languageEnglish (US)
Pages (from-to)299-322
Number of pages24
JournalAnnual Review of Neuroscience
Volume41
DOIs
StatePublished - Jul 8 2018

Fingerprint

Brain Diseases
Neurotransmitter Agents
Neuronal Plasticity
Long-Term Potentiation
Autistic Disorder
Intellectual Disability
Neurodegenerative Diseases
Synapses
Substance-Related Disorders
Schizophrenia
Central Nervous System
Learning
Brain
Proteins

Keywords

  • function
  • homeostatic
  • LTD
  • LTP
  • modulation
  • presynaptic
  • structure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Long-term plasticity of neurotransmitter release : Emerging mechanisms and contributions to brain function and disease. / Monday, Hannah R.; Younts, Thomas J.; Castillo, Pablo E.

In: Annual Review of Neuroscience, Vol. 41, 08.07.2018, p. 299-322.

Research output: Contribution to journalReview article

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