Abstract
Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 328-338 |
| Number of pages | 11 |
| Journal | Current Opinion in Neurobiology |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2011 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Long-term plasticity at inhibitory synapses. / Castillo, Pablo E.; Chiu, Chiayu Q.; Carroll, Reed C.
In: Current Opinion in Neurobiology, Vol. 21, No. 2, 04.2011, p. 328-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term plasticity at inhibitory synapses
AU - Castillo, Pablo E.
AU - Chiu, Chiayu Q.
AU - Carroll, Reed C.
PY - 2011/4
Y1 - 2011/4
N2 - Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.
AB - Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.
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UR - http://www.scopus.com/inward/citedby.url?scp=79955661519&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2011.01.006
DO - 10.1016/j.conb.2011.01.006
M3 - Article
VL - 21
SP - 328
EP - 338
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 2
ER -