TY - JOUR
T1 - Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer
AU - Castle, Philip E.
AU - Rodríguez, Ana Cecilia
AU - Burk, Robert D.
AU - Herrero, Rolando
AU - Wacholder, Sholom
AU - Hildesheim, Allan
AU - Morales, Jorge
AU - Rydzak, Greg
AU - Schiffman, Mark
PY - 2011/3/15
Y1 - 2011/3/15
N2 - Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical precancer. Cervical specimens were tested for >40 HPV genotypes using a MY09/11 L1-targeted polymerase chain reaction method. Results. Seventy-two prevalently-detected HPV infections (5%) in 58 women (7%) persisted until the end of the follow-up period (median duration of follow-up, 7 years) without evidence of cervical precancer. At enrollment, women with long-term persistence were more likely to have multiple prevalently-detected HPV infections (P<.001) than were women who cleared their baseline HPV infections during follow-up. In a logistic regression model, women with long-term persistence were more likely than women who cleared infections to have another newly-detected HPV infection detectable at ≥3 visits (odds ratio, 2.6; 95% confidence interval, 1.2-5.6). Conclusions. Women with long-term persistence of HPV infection appear to be generally more susceptible to other HPV infections, especially longer-lasting infections, than are women who cleared their HPV infections.
AB - Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical precancer. Cervical specimens were tested for >40 HPV genotypes using a MY09/11 L1-targeted polymerase chain reaction method. Results. Seventy-two prevalently-detected HPV infections (5%) in 58 women (7%) persisted until the end of the follow-up period (median duration of follow-up, 7 years) without evidence of cervical precancer. At enrollment, women with long-term persistence were more likely to have multiple prevalently-detected HPV infections (P<.001) than were women who cleared their baseline HPV infections during follow-up. In a logistic regression model, women with long-term persistence were more likely than women who cleared infections to have another newly-detected HPV infection detectable at ≥3 visits (odds ratio, 2.6; 95% confidence interval, 1.2-5.6). Conclusions. Women with long-term persistence of HPV infection appear to be generally more susceptible to other HPV infections, especially longer-lasting infections, than are women who cleared their HPV infections.
UR - http://www.scopus.com/inward/record.url?scp=79952332930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952332930&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiq116
DO - 10.1093/infdis/jiq116
M3 - Article
C2 - 21343148
AN - SCOPUS:79952332930
SN - 0022-1899
VL - 203
SP - 814
EP - 822
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -