Long-Term Outcomes: What Should the Focus Be?

Judy L. Aschner, Michele C. Walsh

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The neonatal intervention trials of the 1980s and early 1990s focused primarily on short-term outcomes. Contemporary clinical trials have recognized the importance of longer-term outcomes but have rarely been powered to achieve that aim. This review discusses important and clinically relevant outcomes that future trials should be powered to address and identifies the challenges facing the neonatal clinical trials community. These challenges include consensus definitions of relevant outcomes that are objective and validated, variability among centers in populations and practices, and the need for predictive surrogate markers of long-term outcomes. Future trials must be designed and powered to address the potential for harm as well as the prospect of benefit.

Original languageEnglish (US)
Pages (from-to)205-217
Number of pages13
JournalClinics in Perinatology
Volume34
Issue number1
DOIs
Publication statusPublished - Mar 1 2007

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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