Long-Term Outcomes of Multiple-Wire Localizations for More Extensive Breast Cancer: Multiple-Wire Excision Does Not Increase Recurrence, Unplanned Imaging, or Biopsies

Carson L. Brown, Maureen P. McEvoy, Barbara L. Smith, Conor R. Lanahan, Bridget N. Kelly, Suzanne B. Coopey, Kevin S. Hughes, T. Salewa Oseni, Caroline McGugin, Stephanie M. Wong, Michele A. Gadd, Michelle C. Specht

Research output: Contribution to journalArticle

Abstract

BACKGROUND: We previously reported that breast conservation was feasible for women with large or irregularly shaped breast cancers when tumor resection was guided by multiple localizing wires. We now report long-term outcomes of multiple-wire versus single-wire localized lumpectomies for breast cancer. PATIENTS AND METHODS: We retrospectively reviewed wire-localized lumpectomies at our institution from May 2000 to November 2006. Rates of ipsilateral in-breast tumor recurrence, metastasis, and subsequent unplanned diagnostic imaging and biopsy were compared between multiple-wire and single-wire cohorts. RESULTS: We identified 112 multiple-wire and 160 single-wire breast cancer lumpectomies that achieved clear margins. Median age was 64 years in the multiple-wire cohort and 57 years in the single-wire cohort. Mean lumpectomy volume was 75 mL in multiple-wire patients and 49 mL in single-wire patients (P = .003). Invasive tumor size, axillary node status, and use of radiation and systemic therapy were similar, but the multiple-wire group had more patients with ductal carcinoma-in-situ only (38% vs. 28%). At 108 months' median follow-up, there was no significant difference in local or distant recurrence rates between multiple-wire and single-wire cohorts. Six (5%) multiple-wire patients and 6 (4%) single-wire patients had local recurrences and 3 (3%) multiple-wire and 5 (3%) single-wire patients developed metastatic disease. Unplanned diagnostic imaging was required for 53 (47%) multiple-wire and 65 (41%) single-wire patients. Subsequent ipsilateral biopsy occurred in 15 (13%) multiple-wire and 19 (12%) single-wire patients. CONCLUSION: Breast-conserving surgery with multiple localizing wires is a safe alternative to mastectomy for breast cancer patients with large mammographic lesions.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalClinical breast cancer
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2020

Keywords

  • Breast conservation
  • Breast lumpectomy
  • Large mammographic lesions
  • Overall survival
  • Wire-localized lumpectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Brown, C. L., McEvoy, M. P., Smith, B. L., Lanahan, C. R., Kelly, B. N., Coopey, S. B., Hughes, K. S., Oseni, T. S., McGugin, C., Wong, S. M., Gadd, M. A., & Specht, M. C. (2020). Long-Term Outcomes of Multiple-Wire Localizations for More Extensive Breast Cancer: Multiple-Wire Excision Does Not Increase Recurrence, Unplanned Imaging, or Biopsies. Clinical breast cancer, 20(3), 215-219. https://doi.org/10.1016/j.clbc.2019.11.006