Long-term outcomes for children with acute lymphoblastic leukemia (ALL) treated on The Cancer Institute of New Jersey ALL trial (CINJALL)

Richard A. Drachtman, Margaret Masterson, Angela Shenkerman, Veena Vijayanathan, Peter D. Cole

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Cancer Institute of New Jersey Acute Lymphoblastic Leukemia trial (CINJALL) employed a post-induction regimen centered on intensive oral antimetabolite therapy, with no intravenous methotrexate (MTX). Fifty-eight patients enrolled between 2001 and 2005. A high rate of induction death (n = 3) or induction failure (n = 1) was observed. Among those who entered remission, five-year DFS is 80 ± 8.9% for those at standard risk of relapse and 76 ± 7.8% for high-risk patients, with median follow up over six years. The estimated cumulative incidence of testicular relapse among boys was elevated (13 ± 7.2%) compared to the rate observed on contemporary protocols. We conclude that post-induction therapy using intensive oral antimetabolites for children with acute lymphoblastic leukemia (ALL) can result in overall long-term DFS comparable to that observed among children treated with regimens including intravenous MTX. However, an increased risk of late extramedullary relapse among boys was observed, supporting the prevailing opinion that high-dose MTX improves outcome for children with ALL.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Feb 12 2016

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Antimetabolites
Recurrence
Neoplasms
Mortality
Incidence
Therapeutics

Keywords

  • Acute lymphoblastic leukemia
  • clinical trials
  • Hispanic
  • methotrexate
  • testicular relapse

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Long-term outcomes for children with acute lymphoblastic leukemia (ALL) treated on The Cancer Institute of New Jersey ALL trial (CINJALL). / Drachtman, Richard A.; Masterson, Margaret; Shenkerman, Angela; Vijayanathan, Veena; Cole, Peter D.

In: Leukemia and Lymphoma, 12.02.2016, p. 1-6.

Research output: Contribution to journalArticle

Drachtman, Richard A. ; Masterson, Margaret ; Shenkerman, Angela ; Vijayanathan, Veena ; Cole, Peter D. / Long-term outcomes for children with acute lymphoblastic leukemia (ALL) treated on The Cancer Institute of New Jersey ALL trial (CINJALL). In: Leukemia and Lymphoma. 2016 ; pp. 1-6.
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