Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats.

K. Wieczorowska-Tobis, K. Korybalska, A. Polubińska, M. Radkowski, A. Breborowicz, A. Montagne, D. G. Oreopoulos

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Abstract

This study was designed to test the morphological and functional effects of neutral, bicarbonate-based peritoneal dialysis solution containing glycylglycine on the peritoneum of chronically dialyzed rats. Peritoneal dialysis catheters were implanted in 36 rats. The animals were dialyzed twice daily for 4 weeks with a solution containing bicarbonate (35 mmol/L), glycylglycine (10 mmol/L), and 4% of anhydrous glucose (pH 7.35) (group 1; n = 18) or with lactate-based standard 4.25% Dianeal (pH 5.3 (group 2; n = 18). At the beginning of the study, reabsorption of glucose was slower in group 1 (p < 0.02); at the same time, the hyaluronic acid level in the effluent was higher in this group (p < 0.05). However, towards the end of the study these differences disappeared. After 4 weeks of dialysis in rats exposed to bicarbonate-based solution only, the transperitoneal loss of proteins was slower. In morphological studies of the parietal peritoneum, we detected no statistically significant differences between control nondialyzed rats and those exposed to tested solutions. In a biopsy of visceral peritoneum a tendency was observed for increased thickness of peritoneum in rats dialyzed with both tested peritoneal dialysis solutions when compared to control animals. In conclusion, neutral pH glycylglycine peritoneal dialysis solutions seem to be more biocompatible than standard dialysis solutions.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalAdvances in peritoneal dialysis. Conference on Peritoneal Dialysis
Volume13
StatePublished - 1997
Externally publishedYes

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Glycylglycine
Peritoneum
Dialysis Solutions
Peritoneal Dialysis
Bicarbonates
Glucose
Hyaluronic Acid
Dialysis
Lactic Acid
Catheters
Biopsy
Proteins

Cite this

Wieczorowska-Tobis, K., Korybalska, K., Polubińska, A., Radkowski, M., Breborowicz, A., Montagne, A., & Oreopoulos, D. G. (1997). Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 13, 42-46.

Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats. / Wieczorowska-Tobis, K.; Korybalska, K.; Polubińska, A.; Radkowski, M.; Breborowicz, A.; Montagne, A.; Oreopoulos, D. G.

In: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Vol. 13, 1997, p. 42-46.

Research output: Contribution to journalArticle

Wieczorowska-Tobis, K, Korybalska, K, Polubińska, A, Radkowski, M, Breborowicz, A, Montagne, A & Oreopoulos, DG 1997, 'Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats.', Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, vol. 13, pp. 42-46.
Wieczorowska-Tobis K, Korybalska K, Polubińska A, Radkowski M, Breborowicz A, Montagne A et al. Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 1997;13:42-46.
Wieczorowska-Tobis, K. ; Korybalska, K. ; Polubińska, A. ; Radkowski, M. ; Breborowicz, A. ; Montagne, A. ; Oreopoulos, D. G. / Long-term effects of glycylglycine peritoneal dialysis solution with neutral pH on peritoneum in rats. In: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 1997 ; Vol. 13. pp. 42-46.
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