Long-term association between seizure outcome and depression after resective epilepsy surgery

Hamada Hamid, H. Liu, X. Cong, O. Devinsky, A. T. Berg, B. G. Vickrey, M. R. Sperling, Shlomo Shinnar, J. T. Langfitt, T. S. Walczak, W. B. Barr, J. Dziura, C. W. Bazil, S. S. Spencer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. Methods: Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case status (none, mild, or moderate/severe) were assessed using the Beck Depression Inventory (BDI) preoperatively and 3, 12, 24, 48, and 60 months postoperatively. A mixed-model repeated-measures analysis was performed, adjusting for covariates of seizure location, gender, age, race, education, and seizure control. Results: Of the total 373 subjects, 256 were evaluated at baseline and 5 years after surgery. At baseline, 164 (64.1%) were not depressed, 34 (13.3%) were mildly depressed, and 58 (22.7%) had moderate to severe depression. After 5 years, 198 (77.3%) were not depressed, 20 (7.8%) were mildly depressed, and 38 (14.8%) were moderately to severely depressed. Five years after surgery, the reduction in mean change from baseline in BDI score was greater in subjects with excellent seizure control than in the fair and poor seizure control groups (p = 0.0006 and p = 0.02 respectively). Those with good seizure control had a greater reduction in BDI score than the poor seizure control group (p = 0.02) and borderline significant reduction compared with the fair seizure control group (p = 0.055). Conclusion: Although study participants had initial improvement in depressive symptoms, on average, after resective surgery, only patients with good or excellent seizure control had sustained long-term improvement in mood.

Original languageEnglish (US)
Pages (from-to)1972-1976
Number of pages5
JournalNeurology
Volume77
Issue number22
DOIs
StatePublished - Nov 29 2011
Externally publishedYes

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Epilepsy
Seizures
Depression
Equipment and Supplies
Control Groups
Surgery
Multicenter Studies
Prospective Studies
Education
Depressive Symptoms
Control Group

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Hamid, H., Liu, H., Cong, X., Devinsky, O., Berg, A. T., Vickrey, B. G., ... Spencer, S. S. (2011). Long-term association between seizure outcome and depression after resective epilepsy surgery. Neurology, 77(22), 1972-1976. https://doi.org/10.1212/WNL.0b013e31823a0c90

Long-term association between seizure outcome and depression after resective epilepsy surgery. / Hamid, Hamada; Liu, H.; Cong, X.; Devinsky, O.; Berg, A. T.; Vickrey, B. G.; Sperling, M. R.; Shinnar, Shlomo; Langfitt, J. T.; Walczak, T. S.; Barr, W. B.; Dziura, J.; Bazil, C. W.; Spencer, S. S.

In: Neurology, Vol. 77, No. 22, 29.11.2011, p. 1972-1976.

Research output: Contribution to journalArticle

Hamid, H, Liu, H, Cong, X, Devinsky, O, Berg, AT, Vickrey, BG, Sperling, MR, Shinnar, S, Langfitt, JT, Walczak, TS, Barr, WB, Dziura, J, Bazil, CW & Spencer, SS 2011, 'Long-term association between seizure outcome and depression after resective epilepsy surgery', Neurology, vol. 77, no. 22, pp. 1972-1976. https://doi.org/10.1212/WNL.0b013e31823a0c90
Hamid, Hamada ; Liu, H. ; Cong, X. ; Devinsky, O. ; Berg, A. T. ; Vickrey, B. G. ; Sperling, M. R. ; Shinnar, Shlomo ; Langfitt, J. T. ; Walczak, T. S. ; Barr, W. B. ; Dziura, J. ; Bazil, C. W. ; Spencer, S. S. / Long-term association between seizure outcome and depression after resective epilepsy surgery. In: Neurology. 2011 ; Vol. 77, No. 22. pp. 1972-1976.
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abstract = "Objective: This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. Methods: Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case status (none, mild, or moderate/severe) were assessed using the Beck Depression Inventory (BDI) preoperatively and 3, 12, 24, 48, and 60 months postoperatively. A mixed-model repeated-measures analysis was performed, adjusting for covariates of seizure location, gender, age, race, education, and seizure control. Results: Of the total 373 subjects, 256 were evaluated at baseline and 5 years after surgery. At baseline, 164 (64.1{\%}) were not depressed, 34 (13.3{\%}) were mildly depressed, and 58 (22.7{\%}) had moderate to severe depression. After 5 years, 198 (77.3{\%}) were not depressed, 20 (7.8{\%}) were mildly depressed, and 38 (14.8{\%}) were moderately to severely depressed. Five years after surgery, the reduction in mean change from baseline in BDI score was greater in subjects with excellent seizure control than in the fair and poor seizure control groups (p = 0.0006 and p = 0.02 respectively). Those with good seizure control had a greater reduction in BDI score than the poor seizure control group (p = 0.02) and borderline significant reduction compared with the fair seizure control group (p = 0.055). Conclusion: Although study participants had initial improvement in depressive symptoms, on average, after resective surgery, only patients with good or excellent seizure control had sustained long-term improvement in mood.",
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AU - Hamid, Hamada

AU - Liu, H.

AU - Cong, X.

AU - Devinsky, O.

AU - Berg, A. T.

AU - Vickrey, B. G.

AU - Sperling, M. R.

AU - Shinnar, Shlomo

AU - Langfitt, J. T.

AU - Walczak, T. S.

AU - Barr, W. B.

AU - Dziura, J.

AU - Bazil, C. W.

AU - Spencer, S. S.

PY - 2011/11/29

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N2 - Objective: This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. Methods: Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case status (none, mild, or moderate/severe) were assessed using the Beck Depression Inventory (BDI) preoperatively and 3, 12, 24, 48, and 60 months postoperatively. A mixed-model repeated-measures analysis was performed, adjusting for covariates of seizure location, gender, age, race, education, and seizure control. Results: Of the total 373 subjects, 256 were evaluated at baseline and 5 years after surgery. At baseline, 164 (64.1%) were not depressed, 34 (13.3%) were mildly depressed, and 58 (22.7%) had moderate to severe depression. After 5 years, 198 (77.3%) were not depressed, 20 (7.8%) were mildly depressed, and 38 (14.8%) were moderately to severely depressed. Five years after surgery, the reduction in mean change from baseline in BDI score was greater in subjects with excellent seizure control than in the fair and poor seizure control groups (p = 0.0006 and p = 0.02 respectively). Those with good seizure control had a greater reduction in BDI score than the poor seizure control group (p = 0.02) and borderline significant reduction compared with the fair seizure control group (p = 0.055). Conclusion: Although study participants had initial improvement in depressive symptoms, on average, after resective surgery, only patients with good or excellent seizure control had sustained long-term improvement in mood.

AB - Objective: This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. Methods: Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case status (none, mild, or moderate/severe) were assessed using the Beck Depression Inventory (BDI) preoperatively and 3, 12, 24, 48, and 60 months postoperatively. A mixed-model repeated-measures analysis was performed, adjusting for covariates of seizure location, gender, age, race, education, and seizure control. Results: Of the total 373 subjects, 256 were evaluated at baseline and 5 years after surgery. At baseline, 164 (64.1%) were not depressed, 34 (13.3%) were mildly depressed, and 58 (22.7%) had moderate to severe depression. After 5 years, 198 (77.3%) were not depressed, 20 (7.8%) were mildly depressed, and 38 (14.8%) were moderately to severely depressed. Five years after surgery, the reduction in mean change from baseline in BDI score was greater in subjects with excellent seizure control than in the fair and poor seizure control groups (p = 0.0006 and p = 0.02 respectively). Those with good seizure control had a greater reduction in BDI score than the poor seizure control group (p = 0.02) and borderline significant reduction compared with the fair seizure control group (p = 0.055). Conclusion: Although study participants had initial improvement in depressive symptoms, on average, after resective surgery, only patients with good or excellent seizure control had sustained long-term improvement in mood.

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