Long noncoding RNAs in cancer: From discovery to therapeutic targets

Ramesh Choudhari, Melina J. Sedano, Alana L. Harrison, Ramadevi Subramani, Ken Y. Lin, Enrique I. Ramos, Rajkumar Lakshmanaswamy, Shrikanth S. Gadad

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key players in biological regulation; however, the mechanisms by which lncRNAs govern various disease processes remain mysterious and are just beginning to be understood. The ease of next-generation sequencing technologies has led to an explosion of genomic information, especially for the lncRNA class of noncoding RNAs. LncRNAs exhibit the characteristics of mRNAs, such as polyadenylation, 5′ methyl capping, RNA polymerase II-dependent transcription, and splicing. These transcripts comprise more than 200 nucleotides (nt) and are not translated into proteins. Directed interrogation of annotated lncRNAs from RNA-Seq datasets has revealed dramatic differences in their expression, largely driven by alterations in transcription, the cell cycle, and RNA metabolism. The fact that lncRNAs are expressed cell- and tissue-specifically makes them excellent biomarkers for ongoing biological events. Notably, lncRNAs are differentially expressed in several cancers and show a distinct association with clinical outcomes. Novel methods and strategies are being developed to study lncRNA function and will provide researchers with the tools and opportunities to develop lncRNA-based therapeutics for cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
PublisherAcademic Press Inc.
Pages105-147
Number of pages43
ISBN (Print)9780128211656
DOIs
StatePublished - 2020

Publication series

NameAdvances in Clinical Chemistry
Volume95
ISSN (Print)0065-2423
ISSN (Electronic)2162-9471

Keywords

  • Cancer
  • Long noncoding RNAs
  • Next-generation sequencing
  • Noncoding RNAs
  • Oncogene
  • Tumor suppressor

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

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  • Cite this

    Choudhari, R., Sedano, M. J., Harrison, A. L., Subramani, R., Lin, K. Y., Ramos, E. I., Lakshmanaswamy, R., & Gadad, S. S. (2020). Long noncoding RNAs in cancer: From discovery to therapeutic targets. In G. S. Makowski (Ed.), Advances in Clinical Chemistry (pp. 105-147). (Advances in Clinical Chemistry; Vol. 95). Academic Press Inc.. https://doi.org/10.1016/bs.acc.2019.08.003