Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women

Rochelle Green, Rachel Broadwin, Brian Malig, Rupa Basu, Ellen B. Gold, Lihong Qi, Barbara Sternfeld, Joyce T. Bromberger, Gail A. Greendale, Howard M. Kravitz, Kristin Tomey, Karen Matthews, Carol A. Derby, Elizabeth A. Jackson, Robin Green, Bart Ostro

Research output: Contribution to journalArticle

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Abstract

Background: Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain. Methods: We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein, fibrinogen, tissue-type plasminogen activator antigen, plasminogen activator inhibitor type 1, and factor VIIc (factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, 6-month, 1-month, and 1-day exposures and their relations to serum markers using longitudinal mixed models. Results: For the 2,086 women studied from 1999 to 2004, PM2.5 exposures were associated with all blood markers except factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were strongest for prior year exposures for high-sensitivity C-reactive protein (21% increase per 10 μg/m3 PM2.5, 95% confidence interval [CI]: 6.6, 37), tissue-type plasminogen activator antigen (8.6%, 95% CI: 1.8, 16), and plasminogen activator inhibitor (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5). Conclusions: Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalEpidemiology
Volume27
Issue number2
DOIs
StatePublished - Jan 28 2016

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Ozone
Air Pollution
Hemostatics
Confidence Intervals
Tissue Plasminogen Activator
C-Reactive Protein
Biomarkers
Antigens
Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Women's Health
Fibrinogen
Longitudinal Studies
Body Mass Index
Cardiovascular Diseases
Smoking
Alcohols
Education
Mortality
factor VII clotting antigen

ASJC Scopus subject areas

  • Epidemiology

Cite this

Green, R., Broadwin, R., Malig, B., Basu, R., Gold, E. B., Qi, L., ... Ostro, B. (2016). Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women. Epidemiology, 27(2), 211-220. https://doi.org/10.1097/EDE.0000000000000421

Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women. / Green, Rochelle; Broadwin, Rachel; Malig, Brian; Basu, Rupa; Gold, Ellen B.; Qi, Lihong; Sternfeld, Barbara; Bromberger, Joyce T.; Greendale, Gail A.; Kravitz, Howard M.; Tomey, Kristin; Matthews, Karen; Derby, Carol A.; Jackson, Elizabeth A.; Green, Robin; Ostro, Bart.

In: Epidemiology, Vol. 27, No. 2, 28.01.2016, p. 211-220.

Research output: Contribution to journalArticle

Green, R, Broadwin, R, Malig, B, Basu, R, Gold, EB, Qi, L, Sternfeld, B, Bromberger, JT, Greendale, GA, Kravitz, HM, Tomey, K, Matthews, K, Derby, CA, Jackson, EA, Green, R & Ostro, B 2016, 'Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women', Epidemiology, vol. 27, no. 2, pp. 211-220. https://doi.org/10.1097/EDE.0000000000000421
Green, Rochelle ; Broadwin, Rachel ; Malig, Brian ; Basu, Rupa ; Gold, Ellen B. ; Qi, Lihong ; Sternfeld, Barbara ; Bromberger, Joyce T. ; Greendale, Gail A. ; Kravitz, Howard M. ; Tomey, Kristin ; Matthews, Karen ; Derby, Carol A. ; Jackson, Elizabeth A. ; Green, Robin ; Ostro, Bart. / Long- and short-term exposure to air pollution and inflammatory/hemostatic markers in midlife women. In: Epidemiology. 2016 ; Vol. 27, No. 2. pp. 211-220.
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abstract = "Background: Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain. Methods: We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein, fibrinogen, tissue-type plasminogen activator antigen, plasminogen activator inhibitor type 1, and factor VIIc (factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, 6-month, 1-month, and 1-day exposures and their relations to serum markers using longitudinal mixed models. Results: For the 2,086 women studied from 1999 to 2004, PM2.5 exposures were associated with all blood markers except factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were strongest for prior year exposures for high-sensitivity C-reactive protein (21{\%} increase per 10 μg/m3 PM2.5, 95{\%} confidence interval [CI]: 6.6, 37), tissue-type plasminogen activator antigen (8.6{\%}, 95{\%} CI: 1.8, 16), and plasminogen activator inhibitor (35{\%}, 95{\%} CI: 19, 53). An association was also observed between year prior ozone exposure and factor VIIc (5.7{\%} increase per 10 ppb ozone, 95{\%} CI: 2.9, 8.5). Conclusions: Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.",
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AU - Malig, Brian

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AU - Gold, Ellen B.

AU - Qi, Lihong

AU - Sternfeld, Barbara

AU - Bromberger, Joyce T.

AU - Greendale, Gail A.

AU - Kravitz, Howard M.

AU - Tomey, Kristin

AU - Matthews, Karen

AU - Derby, Carol A.

AU - Jackson, Elizabeth A.

AU - Green, Robin

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N2 - Background: Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain. Methods: We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein, fibrinogen, tissue-type plasminogen activator antigen, plasminogen activator inhibitor type 1, and factor VIIc (factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, 6-month, 1-month, and 1-day exposures and their relations to serum markers using longitudinal mixed models. Results: For the 2,086 women studied from 1999 to 2004, PM2.5 exposures were associated with all blood markers except factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were strongest for prior year exposures for high-sensitivity C-reactive protein (21% increase per 10 μg/m3 PM2.5, 95% confidence interval [CI]: 6.6, 37), tissue-type plasminogen activator antigen (8.6%, 95% CI: 1.8, 16), and plasminogen activator inhibitor (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5). Conclusions: Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.

AB - Background: Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain. Methods: We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein, fibrinogen, tissue-type plasminogen activator antigen, plasminogen activator inhibitor type 1, and factor VIIc (factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, 6-month, 1-month, and 1-day exposures and their relations to serum markers using longitudinal mixed models. Results: For the 2,086 women studied from 1999 to 2004, PM2.5 exposures were associated with all blood markers except factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were strongest for prior year exposures for high-sensitivity C-reactive protein (21% increase per 10 μg/m3 PM2.5, 95% confidence interval [CI]: 6.6, 37), tissue-type plasminogen activator antigen (8.6%, 95% CI: 1.8, 16), and plasminogen activator inhibitor (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5). Conclusions: Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.

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