Locoweed-induced neuronal storage disease characterized by meganeurite formation

S. U. Walkley, L. F. James

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Golgi staining was performed on cerebral cortex and thalamus of adult animals chronically intoxicated with an α-mannosidase inhibitor found in locoweed (Astragalus lentiginosus). The widespread occurrence of large, aspiny meganeurites was discovered on cortical pyramidal and thalamic principal neurons but aberrant spines and neurite growth were not observed. Ectopic neurite growth is known to be characteristics of α-mannosidosis of early onset in inherited and induced feline models. The absence of neuritogenesis in a storage disease known to be so characterized when induced in younger animals suggests that this unusual phenomenon is in some way linked to normal developmental processes associated with brain maturation.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalBrain Research
Volume324
Issue number1
DOIs
StatePublished - Dec 17 1984

Keywords

  • animal models
  • cortical neurons
  • lysosomes
  • mannosidosis
  • neurite growth
  • storage disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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