Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

Subra Kugathasan, Robert N. Baldassano, Jonathan P. Bradfield, Patrick M.A. Sleiman, Marcin Imielinski, Stephen L. Guthery, Salvatore Cucchiara, Cecilia E. Kim, Edward C. Frackelton, Kiran Annaiah, Joseph T. Glessner, Erin Santa, Tara Willson, Andrew W. Eckert, Erin Bonkowski, Julie L. Shaner, Ryan M. Smith, F. George Otieno, Nicholas Peterson, Debra J. AbramsRosetta M. Chiavacci, Robert Grundmeier, Petar Mamula, Gitit Tomer, David A. Piccoli, Dimitri S. Monos, Vito Annese, Lee A. Denson, Struan F.A. Grant, Hakon Hakonarson

Research output: Contribution to journalArticle

237 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal barrier and persistent dysregulation of the immune response to commensal intestinal bacteria. IBD is characterized by two distinct phenotypes: Crohn's disease (CD) and ulcerative colitis (UC). Previously reported GWA studies have identified genetic variation accounting for a small portion of the overall genetic susceptibility to CD and an even smaller contribution to UC pathogenesis. We hypothesized that stratification of IBD by age of onset might identify additional genes associated with IBD. To that end, we carried out a GWA analysis in a cohort of 1,011 individuals with pediatric-onset IBD and 4,250 matched controls. We identified and replicated significantly associated, previously unreported loci on chromosomes 20q13 (rs2315008[T] and rs4809330[A]; P = 6.30 × 10-8 and 6.95 × 10-8, respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 × 10-8; OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively.

Original languageEnglish (US)
Pages (from-to)1211-1215
Number of pages5
JournalNature Genetics
Volume40
Issue number10
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Kugathasan, S., Baldassano, R. N., Bradfield, J. P., Sleiman, P. M. A., Imielinski, M., Guthery, S. L., Cucchiara, S., Kim, C. E., Frackelton, E. C., Annaiah, K., Glessner, J. T., Santa, E., Willson, T., Eckert, A. W., Bonkowski, E., Shaner, J. L., Smith, R. M., Otieno, F. G., Peterson, N., ... Hakonarson, H. (2008). Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nature Genetics, 40(10), 1211-1215. https://doi.org/10.1038/ng.203