Location matters: Somatic and dendritic SK channels answer to distinct calcium signals

Stephanie Rudolph, Monica S. Thanawala

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Voltage- dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart (J Neurosci 33: 19396–19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calciumactivated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of neurophysiology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2015

Keywords

  • Calcium buffering
  • Calcium domains
  • Neuronal excitability
  • SK channel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Location matters: Somatic and dendritic SK channels answer to distinct calcium signals'. Together they form a unique fingerprint.

Cite this