Location matters: Somatic and dendritic SK channels answer to distinct calcium signals

Stephanie Rudolph; Monica S. Thanawala

doi:10.1152/jn.00181.2014

Location matters: Somatic and dendritic SK channels answer to distinct calcium signals

Stephanie Rudolph, Monica S. Thanawala

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Voltage- dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart (J Neurosci 33: 19396–19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calciumactivated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Journal of neurophysiology
Volume	114
Issue number	1
DOIs	https://doi.org/10.1152/jn.00181.2014
State	Published - Jul 1 2015
Externally published	Yes

Keywords

Calcium buffering
Calcium domains
Neuronal excitability
SK channel

ASJC Scopus subject areas

Neuroscience(all)
Physiology

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10.1152/jn.00181.2014

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AB - Voltage- dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart (J Neurosci 33: 19396–19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calciumactivated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals.

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Location matters: Somatic and dendritic SK channels answer to distinct calcium signals

Abstract

Keywords

ASJC Scopus subject areas

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