TY - JOUR
T1 - Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis
AU - Emmert-Buck, Michael R.
AU - Lubensky, Irina A.
AU - Dong, Qihan
AU - Manickam, Pachiappan
AU - Guru, Siradanahalli C.
AU - Kester, Mary Beth
AU - Olufemi, Shodimu Emmanuel
AU - Agarwal, Sunita
AU - Burns, A. Lee
AU - Spiegel, Allen M.
AU - Collins, Francis S.
AU - Marx, Stephen J.
AU - Zhuang, Zhengping
AU - Liotta, Lance A.
AU - Chandrasekharappa, Settara C.
AU - Debelenko, Larisa V.
PY - 1997/5/15
Y1 - 1997/5/15
N2 - Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyzed loss of heterozygosity (LOH) in 188 tumors from 81 patients in an attempt to further define the location of the MEN1 gene. Both tumors from MEN1 patients and corresponding sporadic tumors were analyzed. Tumor types included parathyroid, gastrinoma, pancreatic endocrine, pituitary, and lung carcinoid. Six tumors (three MEN1 and three sporadic tumors) were identified that provided important LOH boundaries. Four tumors (two parathyroid tumors, one gastrinoma, and one lung carcinoid tumor) showed allelic loss that placed the MEN1 gene distal to marker PYGM. Two tumors (one gastrinoma and one parathyroid tumor) showed an LOH boundary that placed the gene proximal to D11S449, one of which further moved the telomeric boundary to D11S4936. Taken together, the present data suggest that the MEN1 gene lies between PYGM and D11S4936, a region of approximately 300 kb on chromosome 11q13.
AB - Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyzed loss of heterozygosity (LOH) in 188 tumors from 81 patients in an attempt to further define the location of the MEN1 gene. Both tumors from MEN1 patients and corresponding sporadic tumors were analyzed. Tumor types included parathyroid, gastrinoma, pancreatic endocrine, pituitary, and lung carcinoid. Six tumors (three MEN1 and three sporadic tumors) were identified that provided important LOH boundaries. Four tumors (two parathyroid tumors, one gastrinoma, and one lung carcinoid tumor) showed allelic loss that placed the MEN1 gene distal to marker PYGM. Two tumors (one gastrinoma and one parathyroid tumor) showed an LOH boundary that placed the gene proximal to D11S449, one of which further moved the telomeric boundary to D11S4936. Taken together, the present data suggest that the MEN1 gene lies between PYGM and D11S4936, a region of approximately 300 kb on chromosome 11q13.
UR - http://www.scopus.com/inward/record.url?scp=15644366487&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15644366487&partnerID=8YFLogxK
M3 - Article
C2 - 9157974
AN - SCOPUS:15644366487
SN - 0008-5472
VL - 57
SP - 1855
EP - 1858
JO - Cancer research
JF - Cancer research
IS - 10
ER -
