Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis

Michael R. Emmert-Buck, Irina A. Lubensky, Qihan Dong, Pachiappan Manickam, Siradanahalli C. Guru, Mary Beth Kester, Shodimu Emmanuel Olufemi, Sunita Agarwal, A. Lee Burns, Allen M. Spiegel, Francis S. Collins, Stephen J. Marx, Zhengping Zhuang, Lance A. Liotta, Settara C. Chandrasekharappa, Larisa V. Debelenko

Research output: Contribution to journalArticle

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Abstract

Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors as well as foregut carcinoids in affected patients. The gene responsible for the disease has been linked to chromosome 11q13. We analyzed loss of heterozygosity (LOH) in 188 tumors from 81 patients in an attempt to further define the location of the MEN1 gene. Both tumors from MEN1 patients and corresponding sporadic tumors were analyzed. Tumor types included parathyroid, gastrinoma, pancreatic endocrine, pituitary, and lung carcinoid. Six tumors (three MEN1 and three sporadic tumors) were identified that provided important LOH boundaries. Four tumors (two parathyroid tumors, one gastrinoma, and one lung carcinoid tumor) showed allelic loss that placed the MEN1 gene distal to marker PYGM. Two tumors (one gastrinoma and one parathyroid tumor) showed an LOH boundary that placed the gene proximal to D11S449, one of which further moved the telomeric boundary to D11S4936. Taken together, the present data suggest that the MEN1 gene lies between PYGM and D11S4936, a region of approximately 300 kb on chromosome 11q13.

Original languageEnglish (US)
Pages (from-to)1855-1858
Number of pages4
JournalCancer Research
Volume57
Issue number10
StatePublished - May 15 1997
Externally publishedYes

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Multiple Endocrine Neoplasia Type 1
Loss of Heterozygosity
Genes
Neoplasms
Gastrinoma
Carcinoid Tumor
Chromosomes
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Emmert-Buck, M. R., Lubensky, I. A., Dong, Q., Manickam, P., Guru, S. C., Kester, M. B., ... Debelenko, L. V. (1997). Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Research, 57(10), 1855-1858.

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. / Emmert-Buck, Michael R.; Lubensky, Irina A.; Dong, Qihan; Manickam, Pachiappan; Guru, Siradanahalli C.; Kester, Mary Beth; Olufemi, Shodimu Emmanuel; Agarwal, Sunita; Burns, A. Lee; Spiegel, Allen M.; Collins, Francis S.; Marx, Stephen J.; Zhuang, Zhengping; Liotta, Lance A.; Chandrasekharappa, Settara C.; Debelenko, Larisa V.

In: Cancer Research, Vol. 57, No. 10, 15.05.1997, p. 1855-1858.

Research output: Contribution to journalArticle

Emmert-Buck, MR, Lubensky, IA, Dong, Q, Manickam, P, Guru, SC, Kester, MB, Olufemi, SE, Agarwal, S, Burns, AL, Spiegel, AM, Collins, FS, Marx, SJ, Zhuang, Z, Liotta, LA, Chandrasekharappa, SC & Debelenko, LV 1997, 'Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis', Cancer Research, vol. 57, no. 10, pp. 1855-1858.
Emmert-Buck MR, Lubensky IA, Dong Q, Manickam P, Guru SC, Kester MB et al. Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Research. 1997 May 15;57(10):1855-1858.
Emmert-Buck, Michael R. ; Lubensky, Irina A. ; Dong, Qihan ; Manickam, Pachiappan ; Guru, Siradanahalli C. ; Kester, Mary Beth ; Olufemi, Shodimu Emmanuel ; Agarwal, Sunita ; Burns, A. Lee ; Spiegel, Allen M. ; Collins, Francis S. ; Marx, Stephen J. ; Zhuang, Zhengping ; Liotta, Lance A. ; Chandrasekharappa, Settara C. ; Debelenko, Larisa V. / Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. In: Cancer Research. 1997 ; Vol. 57, No. 10. pp. 1855-1858.
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