Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter

E. Armstrong, J. Partanen, L. Cannizzaro, K. Huebner, K. Alitalo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-I lymphomas.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalGenes Chromosomes and Cancer
Volume4
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Receptor, Fibroblast Growth Factor, Type 4
Chromosomes
Fibroblast Growth Factor Receptors
Genetic Translocation
Hybrid Cells
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Genes
In Situ Hybridization
Organism Cloning
Lymphoma
Leukemia
Cell Line
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Armstrong, E., Partanen, J., Cannizzaro, L., Huebner, K., & Alitalo, K. (1992). Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter. Genes Chromosomes and Cancer, 4(1), 94-98.

Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter. / Armstrong, E.; Partanen, J.; Cannizzaro, L.; Huebner, K.; Alitalo, K.

In: Genes Chromosomes and Cancer, Vol. 4, No. 1, 1992, p. 94-98.

Research output: Contribution to journalArticle

Armstrong, E, Partanen, J, Cannizzaro, L, Huebner, K & Alitalo, K 1992, 'Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter', Genes Chromosomes and Cancer, vol. 4, no. 1, pp. 94-98.
Armstrong E, Partanen J, Cannizzaro L, Huebner K, Alitalo K. Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter. Genes Chromosomes and Cancer. 1992;4(1):94-98.
Armstrong, E. ; Partanen, J. ; Cannizzaro, L. ; Huebner, K. ; Alitalo, K. / Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter. In: Genes Chromosomes and Cancer. 1992 ; Vol. 4, No. 1. pp. 94-98.
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