Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony

Justin Dauwels, Emad N. Eskandar, Sydney Cash

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Citations (Scopus)

Abstract

For as many as 30% of epilepsy patients, seizures are poorly controlled with medication alone. For some of these patients surgery may be an option: the brain region responsible for seizure onset may be removed surgically. However, this requires accurate delineation of the seizure onset region. Currently, the key to making this determination is seizure EEG. Therefore, EEG recordings must continue until enough seizures are obtained to determine the onset region; this may take about 5 days to several weeks. In some cases these recordings must be done using invasive electrodes, a procedure that includes substantial risk, discomfort and cost. In this paper, techniques are developed that use periods of intracranial non-seizure ("rest") EEG to localize epileptogenic networks. Analysis of intracranial EEG (recorded by surface and/or depth electrodes) of 6 epileptic patients shows that certain EEG channels and hence cortical regions are consistently more synchronous ("hypersynchronous" ) compared to others. It is shown that hypersynchrony seems to strongly correlate with the seizure onset zone; this phenomenon may in the long term allow to determine the seizure onset area(s) from non-seizure EEG, which in turn would enable shorter hospitalizations or even avoidance of semi-chronic implantations all-together.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
Pages2180-2183
Number of pages4
DOIs
StatePublished - Dec 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Electroencephalography
Seizures
Electrodes
Surgery
Brain
Epilepsy
Hospitalization
Costs and Cost Analysis
Costs

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Dauwels, J., Eskandar, E. N., & Cash, S. (2009). Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 2180-2183). [5332447] https://doi.org/10.1109/IEMBS.2009.5332447

Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. / Dauwels, Justin; Eskandar, Emad N.; Cash, Sydney.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 2180-2183 5332447.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dauwels, J, Eskandar, EN & Cash, S 2009, Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5332447, pp. 2180-2183, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5332447
Dauwels J, Eskandar EN, Cash S. Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 2180-2183. 5332447 https://doi.org/10.1109/IEMBS.2009.5332447
Dauwels, Justin ; Eskandar, Emad N. ; Cash, Sydney. / Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 2180-2183
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