Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: A study of 63 cases from four different institutions

Thaer Khoury, Prasanna R. Kumar, Zaibo Li, Rouzan G. Karabakhtsian, Souzan Sanati, Xiwei Chen, Dan Wang, Song Liu, Beatriu Reig

Research output: Contribution to journalArticle

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Abstract

There are certain criteria to recommend surgical excision for lobular neoplasia diagnosed in mammographically detected core biopsy. The aims of this study are to explore the rate of upgrade of lobular neoplasia detected in magnetic resonance imaging (MRI)-guided biopsy and to investigate the clinicopathological and radiological features that could predict upgrade. We reviewed 1655 MRI-guided core biopsies yielding 63 (4%) cases of lobular neoplasia. Key clinical features were recorded. MRI findings including mass vs non-mass enhancement and the reason for biopsy were also recorded. An upgrade was defined as the presence of invasive carcinoma or ductal carcinoma in situ in subsequent surgical excision. The overall rate of lobular neoplasia in MRI-guided core biopsy ranged from 2 to 7%, with an average of 4%. A total of 15 (24%) cases had an upgrade, including 5 cases of invasive carcinoma and 10 cases of ductal carcinoma in situ. Pure lobular neoplasia was identified in 34 cases, 11 (32%) of which had upgrade. In this group, an ipsilateral concurrent or past history of breast cancer was found to be associated with a higher risk of upgrade (6/11, 55%) than contralateral breast cancer (1 of 12, 8%; P=0.03). To our knowledge, this is the largest series of lobular neoplasia diagnosed in MRI-guided core biopsy. The incidence of lobular neoplasia is relatively low. Lobular neoplasia detected in MRI-guided biopsy carries a high risk for upgrade warranting surgical excision. However, more cases from different types of institutions are needed to verify our results.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalModern Pathology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2016

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Image-Guided Biopsy
Magnetic Resonance Imaging
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Carcinoma
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade : A study of 63 cases from four different institutions. / Khoury, Thaer; Kumar, Prasanna R.; Li, Zaibo; Karabakhtsian, Rouzan G.; Sanati, Souzan; Chen, Xiwei; Wang, Dan; Liu, Song; Reig, Beatriu.

In: Modern Pathology, Vol. 29, No. 1, 01.01.2016, p. 25-33.

Research output: Contribution to journalArticle

Khoury, Thaer ; Kumar, Prasanna R. ; Li, Zaibo ; Karabakhtsian, Rouzan G. ; Sanati, Souzan ; Chen, Xiwei ; Wang, Dan ; Liu, Song ; Reig, Beatriu. / Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade : A study of 63 cases from four different institutions. In: Modern Pathology. 2016 ; Vol. 29, No. 1. pp. 25-33.
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abstract = "There are certain criteria to recommend surgical excision for lobular neoplasia diagnosed in mammographically detected core biopsy. The aims of this study are to explore the rate of upgrade of lobular neoplasia detected in magnetic resonance imaging (MRI)-guided biopsy and to investigate the clinicopathological and radiological features that could predict upgrade. We reviewed 1655 MRI-guided core biopsies yielding 63 (4{\%}) cases of lobular neoplasia. Key clinical features were recorded. MRI findings including mass vs non-mass enhancement and the reason for biopsy were also recorded. An upgrade was defined as the presence of invasive carcinoma or ductal carcinoma in situ in subsequent surgical excision. The overall rate of lobular neoplasia in MRI-guided core biopsy ranged from 2 to 7{\%}, with an average of 4{\%}. A total of 15 (24{\%}) cases had an upgrade, including 5 cases of invasive carcinoma and 10 cases of ductal carcinoma in situ. Pure lobular neoplasia was identified in 34 cases, 11 (32{\%}) of which had upgrade. In this group, an ipsilateral concurrent or past history of breast cancer was found to be associated with a higher risk of upgrade (6/11, 55{\%}) than contralateral breast cancer (1 of 12, 8{\%}; P=0.03). To our knowledge, this is the largest series of lobular neoplasia diagnosed in MRI-guided core biopsy. The incidence of lobular neoplasia is relatively low. Lobular neoplasia detected in MRI-guided biopsy carries a high risk for upgrade warranting surgical excision. However, more cases from different types of institutions are needed to verify our results.",
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