Transplantation hepatique avec donneur vivant apparente chez l'enfant

Translated title of the contribution: Liver transplantation with a living related donor in children

Florence Lacaille, Jacques Belghiti, Frédérique Sauvat, Jean Luc Michel, Olivier Farges, Annick Rengeval, Sabine Sarnacki, Natacha Sayegh, Dominique M. Jan, Yann Revillon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives - Liver transplantation with living related donor has been recently developed to compensate for the insufficient number of liver grafts for children. The major problem is ethical because it implies voluntary mutilation of a healthy person. This paper report results in 37 living related donors. Patients - Recipients were followed in Enfants-Malades Hospital. Investigations and donor surgery were performed at the Digestive Surgery Unit of Beaujon Hospital. Results - One donor was re-operated for bleeding, and another one a biliary fistula treated with percutaneous drainage for one week. The post-operative course was uneventful in the other donors, with a follow-up of between 2 and 50 months. Thirty-three children are alive (90%), one of them underwent a second transplant for arterial thrombosis. Vascular and infectious complications, and the number of rejection episodes were the same as in transplantations with a deceased donor. Biliary complications were frequent (15 patients out of 37) and Significantly increased morbidity. A teenage boy who received a small graft (0.9% of his weight) presented initially with hepatic insufficiency without encephalopathy. Conclusion - This technique has been shown to have a good balance between benefits and risks. Our experience confirms this, especially in very young children. Each case should be discussed individually and parental consent should be obtained without external pressure. Experience with this technique should be continued and at the same time the use of cadaveric grafts should be optimized.

Original languageFrench
Pages (from-to)710-716
Number of pages7
JournalGastroenterologie Clinique et Biologique
Volume23
Issue number6-7
StatePublished - 1999
Externally publishedYes

Fingerprint

Living Donors
Liver Transplantation
Tissue Donors
Transplants
Parental Consent
Biliary Fistula
Hepatic Insufficiency
Hospital Units
Brain Diseases
Blood Vessels
Drainage
Thrombosis
Transplantation
Hemorrhage
Morbidity
Pressure
Weights and Measures
Liver

Keywords

  • Biliary complications
  • Liver transplantation
  • Living donor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lacaille, F., Belghiti, J., Sauvat, F., Michel, J. L., Farges, O., Rengeval, A., ... Revillon, Y. (1999). Transplantation hepatique avec donneur vivant apparente chez l'enfant. Gastroenterologie Clinique et Biologique, 23(6-7), 710-716.

Transplantation hepatique avec donneur vivant apparente chez l'enfant. / Lacaille, Florence; Belghiti, Jacques; Sauvat, Frédérique; Michel, Jean Luc; Farges, Olivier; Rengeval, Annick; Sarnacki, Sabine; Sayegh, Natacha; Jan, Dominique M.; Revillon, Yann.

In: Gastroenterologie Clinique et Biologique, Vol. 23, No. 6-7, 1999, p. 710-716.

Research output: Contribution to journalArticle

Lacaille, F, Belghiti, J, Sauvat, F, Michel, JL, Farges, O, Rengeval, A, Sarnacki, S, Sayegh, N, Jan, DM & Revillon, Y 1999, 'Transplantation hepatique avec donneur vivant apparente chez l'enfant', Gastroenterologie Clinique et Biologique, vol. 23, no. 6-7, pp. 710-716.
Lacaille F, Belghiti J, Sauvat F, Michel JL, Farges O, Rengeval A et al. Transplantation hepatique avec donneur vivant apparente chez l'enfant. Gastroenterologie Clinique et Biologique. 1999;23(6-7):710-716.
Lacaille, Florence ; Belghiti, Jacques ; Sauvat, Frédérique ; Michel, Jean Luc ; Farges, Olivier ; Rengeval, Annick ; Sarnacki, Sabine ; Sayegh, Natacha ; Jan, Dominique M. ; Revillon, Yann. / Transplantation hepatique avec donneur vivant apparente chez l'enfant. In: Gastroenterologie Clinique et Biologique. 1999 ; Vol. 23, No. 6-7. pp. 710-716.
@article{b8b76ec4ab7245a3828cdca64c6086c0,
title = "Transplantation hepatique avec donneur vivant apparente chez l'enfant",
abstract = "Objectives - Liver transplantation with living related donor has been recently developed to compensate for the insufficient number of liver grafts for children. The major problem is ethical because it implies voluntary mutilation of a healthy person. This paper report results in 37 living related donors. Patients - Recipients were followed in Enfants-Malades Hospital. Investigations and donor surgery were performed at the Digestive Surgery Unit of Beaujon Hospital. Results - One donor was re-operated for bleeding, and another one a biliary fistula treated with percutaneous drainage for one week. The post-operative course was uneventful in the other donors, with a follow-up of between 2 and 50 months. Thirty-three children are alive (90{\%}), one of them underwent a second transplant for arterial thrombosis. Vascular and infectious complications, and the number of rejection episodes were the same as in transplantations with a deceased donor. Biliary complications were frequent (15 patients out of 37) and Significantly increased morbidity. A teenage boy who received a small graft (0.9{\%} of his weight) presented initially with hepatic insufficiency without encephalopathy. Conclusion - This technique has been shown to have a good balance between benefits and risks. Our experience confirms this, especially in very young children. Each case should be discussed individually and parental consent should be obtained without external pressure. Experience with this technique should be continued and at the same time the use of cadaveric grafts should be optimized.",
keywords = "Biliary complications, Liver transplantation, Living donor",
author = "Florence Lacaille and Jacques Belghiti and Fr{\'e}d{\'e}rique Sauvat and Michel, {Jean Luc} and Olivier Farges and Annick Rengeval and Sabine Sarnacki and Natacha Sayegh and Jan, {Dominique M.} and Yann Revillon",
year = "1999",
language = "French",
volume = "23",
pages = "710--716",
journal = "Clinics and Research in Hepatology and Gastroenterology",
issn = "2210-7401",
publisher = "Elsevier Masson",
number = "6-7",

}

TY - JOUR

T1 - Transplantation hepatique avec donneur vivant apparente chez l'enfant

AU - Lacaille, Florence

AU - Belghiti, Jacques

AU - Sauvat, Frédérique

AU - Michel, Jean Luc

AU - Farges, Olivier

AU - Rengeval, Annick

AU - Sarnacki, Sabine

AU - Sayegh, Natacha

AU - Jan, Dominique M.

AU - Revillon, Yann

PY - 1999

Y1 - 1999

N2 - Objectives - Liver transplantation with living related donor has been recently developed to compensate for the insufficient number of liver grafts for children. The major problem is ethical because it implies voluntary mutilation of a healthy person. This paper report results in 37 living related donors. Patients - Recipients were followed in Enfants-Malades Hospital. Investigations and donor surgery were performed at the Digestive Surgery Unit of Beaujon Hospital. Results - One donor was re-operated for bleeding, and another one a biliary fistula treated with percutaneous drainage for one week. The post-operative course was uneventful in the other donors, with a follow-up of between 2 and 50 months. Thirty-three children are alive (90%), one of them underwent a second transplant for arterial thrombosis. Vascular and infectious complications, and the number of rejection episodes were the same as in transplantations with a deceased donor. Biliary complications were frequent (15 patients out of 37) and Significantly increased morbidity. A teenage boy who received a small graft (0.9% of his weight) presented initially with hepatic insufficiency without encephalopathy. Conclusion - This technique has been shown to have a good balance between benefits and risks. Our experience confirms this, especially in very young children. Each case should be discussed individually and parental consent should be obtained without external pressure. Experience with this technique should be continued and at the same time the use of cadaveric grafts should be optimized.

AB - Objectives - Liver transplantation with living related donor has been recently developed to compensate for the insufficient number of liver grafts for children. The major problem is ethical because it implies voluntary mutilation of a healthy person. This paper report results in 37 living related donors. Patients - Recipients were followed in Enfants-Malades Hospital. Investigations and donor surgery were performed at the Digestive Surgery Unit of Beaujon Hospital. Results - One donor was re-operated for bleeding, and another one a biliary fistula treated with percutaneous drainage for one week. The post-operative course was uneventful in the other donors, with a follow-up of between 2 and 50 months. Thirty-three children are alive (90%), one of them underwent a second transplant for arterial thrombosis. Vascular and infectious complications, and the number of rejection episodes were the same as in transplantations with a deceased donor. Biliary complications were frequent (15 patients out of 37) and Significantly increased morbidity. A teenage boy who received a small graft (0.9% of his weight) presented initially with hepatic insufficiency without encephalopathy. Conclusion - This technique has been shown to have a good balance between benefits and risks. Our experience confirms this, especially in very young children. Each case should be discussed individually and parental consent should be obtained without external pressure. Experience with this technique should be continued and at the same time the use of cadaveric grafts should be optimized.

KW - Biliary complications

KW - Liver transplantation

KW - Living donor

UR - http://www.scopus.com/inward/record.url?scp=0032799858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032799858&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 710

EP - 716

JO - Clinics and Research in Hepatology and Gastroenterology

JF - Clinics and Research in Hepatology and Gastroenterology

SN - 2210-7401

IS - 6-7

ER -