Abstract
Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 238-242 |
| Number of pages | 5 |
| Journal | The Journal of Pediatrics |
| Volume | 81 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1972 |
Fingerprint
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Liver disease in the drug-using adolescent. / Litt, Iris F.; Cohen, Michael I.; Schonberg, S. Kenneth; Spigland, Ilya.
In: The Journal of Pediatrics, Vol. 81, No. 2, 1972, p. 238-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liver disease in the drug-using adolescent
AU - Litt, Iris F.
AU - Cohen, Michael I.
AU - Schonberg, S. Kenneth
AU - Spigland, Ilya
PY - 1972
Y1 - 1972
N2 - Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.
AB - Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.
UR - http://www.scopus.com/inward/record.url?scp=0015383188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015383188&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(72)80289-0
DO - 10.1016/S0022-3476(72)80289-0
M3 - Article
C2 - 5042483
AN - SCOPUS:0015383188
VL - 81
SP - 238
EP - 242
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 2
ER -