Liver disease in the drug-using adolescent

Iris F. Litt; Michael I. Cohen; S. Kenneth Schonberg; Ilya Spigland

doi:10.1016/S0022-3476(72)80289-0

Liver disease in the drug-using adolescent

Iris F. Litt, Michael I. Cohen, S. Kenneth Schonberg, Ilya Spigland

Pediatrics

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19 Scopus citations

Abstract

Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.

Original language	English (US)
Pages (from-to)	238-242
Number of pages	5
Journal	The Journal of Pediatrics
Volume	81
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(72)80289-0
State	Published - Aug 1972

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Liver disease in the drug-using adolescent",

abstract = "Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.",

author = "Litt, {Iris F.} and Cohen, {Michael I.} and Schonberg, {S. Kenneth} and Ilya Spigland",

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T1 - Liver disease in the drug-using adolescent

AU - Litt, Iris F.

AU - Cohen, Michael I.

AU - Schonberg, S. Kenneth

AU - Spigland, Ilya

N1 - Funding Information: Health Service Research Grant AM 13785 #ore the National Institutes o\[ Arthritis and Metabolic Diseases. " ~

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N2 - Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.

AB - Evaluation of 7,272 presumably well adolescent users of heroin, sedatives and airplane glue revealed abnormalities in liver function in 37 per cent. Elevation of the concentration of serum glutamic pyruvic transaminase was the most common abnormality, while elevation of serum bilirubin levels was recorded in less than 10 per cent. These abnormalities were prevalent in the patients who used heroin and sedatives. Inhalation of airplane glue was not associated with abnormalities in liver function tests. The substances commontly abused by our patients did not appear toxic when tested in an in vitro system designed to evaluate acute hepatotoxicity. The long-term prognosis of chronic persistent hepatitis in teen-agers who abuse drugs is still unknown.

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Liver disease in the drug-using adolescent

Abstract

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