Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

Vasan K. Sambandamurthy, William R. Jacobs

Research output: Contribution to journalShort survey

55 Scopus citations

Abstract

The recent advances in genetic tools to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study of their role in the virulence and pathogenesis of tuberculosis. The safety and vaccine potential of a few of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed.

Original languageEnglish (US)
Pages (from-to)955-961
Number of pages7
JournalMicrobes and Infection
Volume7
Issue number5-6
DOIs
StatePublished - May 2005

Keywords

  • Attenuated
  • Double deletion
  • Pantothenate
  • Tuberculosis
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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