Liposomal palmitoyl-L-asparaginase: characterization and biological activity

João C.S. Jorge; Roman Perez-Soler; José G. Morais; Maria Eugénia M. Cruz

doi:10.1007/BF00685082

Liposomal palmitoyl-L-asparaginase: characterization and biological activity

João C.S. Jorge, Roman Perez-Soler, José G. Morais, Maria Eugénia M. Cruz

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A new derivative of L-asparaginase, palmitoyl-L-asparaginase (palmitoyl-L-ASNase), has been incorporated in liposomes. For this purpose we modified the dehydration-rehydration method and optimized the liposomal composition. The pharmacokinetics, toxicity, and in vivo antitumor activity against P1534 lymphoma of different liposomal palmitoyl-L-ASNase formulations were studied. Liposomal encapsulation of palmitoyl-L-ASNase as compared with free palmitoyl-L-ASNase resulted in a prolongation of the blood half-life (from 2.88 h to longer than 23.7 h), abrogation of acute toxicity, and preservation of in vivo antitumor activity.

Original language	English (US)
Pages (from-to)	230-234
Number of pages	5
Journal	Cancer Chemotherapy and Pharmacology
Volume	34
Issue number	3
DOIs	https://doi.org/10.1007/BF00685082
State	Published - May 1994
Externally published	Yes

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00685082

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title = "Liposomal palmitoyl-L-asparaginase: characterization and biological activity",

abstract = "A new derivative of L-asparaginase, palmitoyl-L-asparaginase (palmitoyl-L-ASNase), has been incorporated in liposomes. For this purpose we modified the dehydration-rehydration method and optimized the liposomal composition. The pharmacokinetics, toxicity, and in vivo antitumor activity against P1534 lymphoma of different liposomal palmitoyl-L-ASNase formulations were studied. Liposomal encapsulation of palmitoyl-L-ASNase as compared with free palmitoyl-L-ASNase resulted in a prolongation of the blood half-life (from 2.88 h to longer than 23.7 h), abrogation of acute toxicity, and preservation of in vivo antitumor activity.",

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year = "1994",

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language = "English (US)",

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T1 - Liposomal palmitoyl-L-asparaginase

T2 - characterization and biological activity

AU - Jorge, João C.S.

AU - Perez-Soler, Roman

AU - Morais, José G.

AU - Cruz, Maria Eugénia M.

PY - 1994/5

Y1 - 1994/5

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AB - A new derivative of L-asparaginase, palmitoyl-L-asparaginase (palmitoyl-L-ASNase), has been incorporated in liposomes. For this purpose we modified the dehydration-rehydration method and optimized the liposomal composition. The pharmacokinetics, toxicity, and in vivo antitumor activity against P1534 lymphoma of different liposomal palmitoyl-L-ASNase formulations were studied. Liposomal encapsulation of palmitoyl-L-ASNase as compared with free palmitoyl-L-ASNase resulted in a prolongation of the blood half-life (from 2.88 h to longer than 23.7 h), abrogation of acute toxicity, and preservation of in vivo antitumor activity.

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Liposomal palmitoyl-L-asparaginase: characterization and biological activity

Abstract

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