Liposomal palmitoyl-L-asparaginase: characterization and biological activity

João C.S. Jorge, Roman Perez-Soler, José G. Morais, Maria Eugénia M. Cruz

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

A new derivative of L-asparaginase, palmitoyl-L-asparaginase (palmitoyl-L-ASNase), has been incorporated in liposomes. For this purpose we modified the dehydration-rehydration method and optimized the liposomal composition. The pharmacokinetics, toxicity, and in vivo antitumor activity against P1534 lymphoma of different liposomal palmitoyl-L-ASNase formulations were studied. Liposomal encapsulation of palmitoyl-L-ASNase as compared with free palmitoyl-L-ASNase resulted in a prolongation of the blood half-life (from 2.88 h to longer than 23.7 h), abrogation of acute toxicity, and preservation of in vivo antitumor activity.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalCancer Chemotherapy and Pharmacology
Volume34
Issue number3
DOIs
StatePublished - May 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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