TY - JOUR
T1 - Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma
AU - Huang, Gloria S.
AU - Juretzka, Margrit
AU - Ciaravino, Giuseppe
AU - Kohler, Sabine
AU - Teng, Nelson N.H.
PY - 2002
Y1 - 2002
N2 - Background. Primary adenocarcinoma of the vulva is a rare entity, and for widely metastatic vulvar adenocarcinoma, no effective treatment has been established. Case. A 65-year-old woman was diagnosed with regionally advanced vulvar adenocarcinoma, with bulky involvement of bilateral groin lymph nodes, and associated extramammary Paget's disease. Initial therapy consisted of multiagent chemotherapy and vulvar and groin irradiation, followed by radical vulvectomy with groin and pelvic lymph node dissection. She subsequently developed widely metastatic disease including brain, pulmonary, hepatic, osseus, and subcutaneous lesions. Treatment with liposomal doxorubicin (Doxil) resulted in dramatic regression of metastatic lesions and marked improvement in quality-of-life. She remains clinically well, greater than 1 year since initiating Doxil treatment for widely metastatic vulvar adenocarcinoma, and has surpassed 5 years of survival since her initial diagnosis. Conclusions. We report the first case of Doxil used for the treatment of metastatic chemorefractory vulvar adenocarcinoma. We observed that Doxil was a well-tolerated and effective agent for this gynecologic malignancy, and warrants further investigation.
AB - Background. Primary adenocarcinoma of the vulva is a rare entity, and for widely metastatic vulvar adenocarcinoma, no effective treatment has been established. Case. A 65-year-old woman was diagnosed with regionally advanced vulvar adenocarcinoma, with bulky involvement of bilateral groin lymph nodes, and associated extramammary Paget's disease. Initial therapy consisted of multiagent chemotherapy and vulvar and groin irradiation, followed by radical vulvectomy with groin and pelvic lymph node dissection. She subsequently developed widely metastatic disease including brain, pulmonary, hepatic, osseus, and subcutaneous lesions. Treatment with liposomal doxorubicin (Doxil) resulted in dramatic regression of metastatic lesions and marked improvement in quality-of-life. She remains clinically well, greater than 1 year since initiating Doxil treatment for widely metastatic vulvar adenocarcinoma, and has surpassed 5 years of survival since her initial diagnosis. Conclusions. We report the first case of Doxil used for the treatment of metastatic chemorefractory vulvar adenocarcinoma. We observed that Doxil was a well-tolerated and effective agent for this gynecologic malignancy, and warrants further investigation.
KW - Adenocarcinoma
KW - Doxorubicin
KW - Extramammary Paget's disease
KW - Liposome
KW - Vulvar neoplasm
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U2 - 10.1006/gyno.2002.6830
DO - 10.1006/gyno.2002.6830
M3 - Article
C2 - 12468332
AN - SCOPUS:0036928246
SN - 0090-8258
VL - 87
SP - 313
EP - 318
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -