Lipoprotein(a) and HIV

Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study

Enkhmaa Byambaa, Anuurad Erdembileg, Wei Zhang, Chin Shang Li, Robert C. Kaplan, Jason Lazar, Dan Merenstein, Roksana Karim, Brad Aouizerat, Mardge Cohen, Kenneth Butler, Savita Pahwa, Igho Ofotokun, Adaora A. Adimora, Elizabeth Golub, Lars Berglund

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE—: In the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. Lp(a) levels are to a major extent regulated by a size polymorphism in the apolipoprotein(a) [apo(a)] gene. The roles of Lp(a)/apo(a) in human immunodeficiency virus (HIV)–related elevated cardiovascular disease risk remain unclear. APPROACH AND RESULTS—: The associations between total plasma Lp(a) level, allele-specific apo(a) level, an Lp(a) level carried by individual apo(a) alleles, and common carotid artery intima–media thickness were assessed in 150 HIV-infected and 100 HIV-uninfected women in the WIHS (Women’s Interagency HIV Study). Linear regression analyses with and without adjustments were used. The cohort was young (mean age, ≈31 years), with the majority being Blacks (≈70%). The prevalence of a small size apo(a) (≤22 Kringle repeats) or a high Lp(a) level (≥30 mg/dL) was similar by HIV status. Total plasma Lp(a) level (P=0.029) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.022) were significantly associated with carotid artery intima–media thickness in the HIV-infected women only. After accounting for confounders (age, race, smoking, body mass index, blood pressure, hepatitis C virus coinfection, menopause, plasma lipids, treatment status, CD4 T cell count, and HIV/RNA viral load), the association remained significant for both Lp(a) (P=0.035) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.010) in the HIV-infected women. Notably, none of the other lipids/lipoproteins was associated with carotid artery intima–media thickness. CONCLUSIONS—: Lp(a) and allele-specific apo(a) levels predict carotid artery intima–media thickness in HIV-infected young women. Further research is needed to identify underlying mechanisms of an increased Lp(a) atherogenicity in HIV infection.

Original languageEnglish (US)
JournalArteriosclerosis, Thrombosis, and Vascular Biology
DOIs
StateAccepted/In press - Mar 23 2017

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Apoprotein(a)
Lipoprotein(a)
Alleles
HIV
Carotid Arteries
Cardiovascular Diseases
Kringles
Lipids
Social Adjustment
Common Carotid Artery
Virus Diseases
CD4 Lymphocyte Count
Menopause
Viral Load
Coinfection
Hepacivirus
Lipoproteins
Linear Models
Body Mass Index
Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lipoprotein(a) and HIV : Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study. / Byambaa, Enkhmaa; Erdembileg, Anuurad; Zhang, Wei; Li, Chin Shang; Kaplan, Robert C.; Lazar, Jason; Merenstein, Dan; Karim, Roksana; Aouizerat, Brad; Cohen, Mardge; Butler, Kenneth; Pahwa, Savita; Ofotokun, Igho; Adimora, Adaora A.; Golub, Elizabeth; Berglund, Lars.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, 23.03.2017.

Research output: Contribution to journalArticle

Byambaa, E, Erdembileg, A, Zhang, W, Li, CS, Kaplan, RC, Lazar, J, Merenstein, D, Karim, R, Aouizerat, B, Cohen, M, Butler, K, Pahwa, S, Ofotokun, I, Adimora, AA, Golub, E & Berglund, L 2017, 'Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study', Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/ATVBAHA.117.309137
Byambaa, Enkhmaa ; Erdembileg, Anuurad ; Zhang, Wei ; Li, Chin Shang ; Kaplan, Robert C. ; Lazar, Jason ; Merenstein, Dan ; Karim, Roksana ; Aouizerat, Brad ; Cohen, Mardge ; Butler, Kenneth ; Pahwa, Savita ; Ofotokun, Igho ; Adimora, Adaora A. ; Golub, Elizabeth ; Berglund, Lars. / Lipoprotein(a) and HIV : Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2017.
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title = "Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study",
abstract = "OBJECTIVE—: In the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. Lp(a) levels are to a major extent regulated by a size polymorphism in the apolipoprotein(a) [apo(a)] gene. The roles of Lp(a)/apo(a) in human immunodeficiency virus (HIV)–related elevated cardiovascular disease risk remain unclear. APPROACH AND RESULTS—: The associations between total plasma Lp(a) level, allele-specific apo(a) level, an Lp(a) level carried by individual apo(a) alleles, and common carotid artery intima–media thickness were assessed in 150 HIV-infected and 100 HIV-uninfected women in the WIHS (Women’s Interagency HIV Study). Linear regression analyses with and without adjustments were used. The cohort was young (mean age, ≈31 years), with the majority being Blacks (≈70{\%}). The prevalence of a small size apo(a) (≤22 Kringle repeats) or a high Lp(a) level (≥30 mg/dL) was similar by HIV status. Total plasma Lp(a) level (P=0.029) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.022) were significantly associated with carotid artery intima–media thickness in the HIV-infected women only. After accounting for confounders (age, race, smoking, body mass index, blood pressure, hepatitis C virus coinfection, menopause, plasma lipids, treatment status, CD4 T cell count, and HIV/RNA viral load), the association remained significant for both Lp(a) (P=0.035) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.010) in the HIV-infected women. Notably, none of the other lipids/lipoproteins was associated with carotid artery intima–media thickness. CONCLUSIONS—: Lp(a) and allele-specific apo(a) levels predict carotid artery intima–media thickness in HIV-infected young women. Further research is needed to identify underlying mechanisms of an increased Lp(a) atherogenicity in HIV infection.",
author = "Enkhmaa Byambaa and Anuurad Erdembileg and Wei Zhang and Li, {Chin Shang} and Kaplan, {Robert C.} and Jason Lazar and Dan Merenstein and Roksana Karim and Brad Aouizerat and Mardge Cohen and Kenneth Butler and Savita Pahwa and Igho Ofotokun and Adimora, {Adaora A.} and Elizabeth Golub and Lars Berglund",
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T1 - Lipoprotein(a) and HIV

T2 - Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima–Media Thickness in HIV-Infected Young Women in the Women’s Interagency HIV Study

AU - Byambaa, Enkhmaa

AU - Erdembileg, Anuurad

AU - Zhang, Wei

AU - Li, Chin Shang

AU - Kaplan, Robert C.

AU - Lazar, Jason

AU - Merenstein, Dan

AU - Karim, Roksana

AU - Aouizerat, Brad

AU - Cohen, Mardge

AU - Butler, Kenneth

AU - Pahwa, Savita

AU - Ofotokun, Igho

AU - Adimora, Adaora A.

AU - Golub, Elizabeth

AU - Berglund, Lars

PY - 2017/3/23

Y1 - 2017/3/23

N2 - OBJECTIVE—: In the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. Lp(a) levels are to a major extent regulated by a size polymorphism in the apolipoprotein(a) [apo(a)] gene. The roles of Lp(a)/apo(a) in human immunodeficiency virus (HIV)–related elevated cardiovascular disease risk remain unclear. APPROACH AND RESULTS—: The associations between total plasma Lp(a) level, allele-specific apo(a) level, an Lp(a) level carried by individual apo(a) alleles, and common carotid artery intima–media thickness were assessed in 150 HIV-infected and 100 HIV-uninfected women in the WIHS (Women’s Interagency HIV Study). Linear regression analyses with and without adjustments were used. The cohort was young (mean age, ≈31 years), with the majority being Blacks (≈70%). The prevalence of a small size apo(a) (≤22 Kringle repeats) or a high Lp(a) level (≥30 mg/dL) was similar by HIV status. Total plasma Lp(a) level (P=0.029) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.022) were significantly associated with carotid artery intima–media thickness in the HIV-infected women only. After accounting for confounders (age, race, smoking, body mass index, blood pressure, hepatitis C virus coinfection, menopause, plasma lipids, treatment status, CD4 T cell count, and HIV/RNA viral load), the association remained significant for both Lp(a) (P=0.035) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.010) in the HIV-infected women. Notably, none of the other lipids/lipoproteins was associated with carotid artery intima–media thickness. CONCLUSIONS—: Lp(a) and allele-specific apo(a) levels predict carotid artery intima–media thickness in HIV-infected young women. Further research is needed to identify underlying mechanisms of an increased Lp(a) atherogenicity in HIV infection.

AB - OBJECTIVE—: In the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. Lp(a) levels are to a major extent regulated by a size polymorphism in the apolipoprotein(a) [apo(a)] gene. The roles of Lp(a)/apo(a) in human immunodeficiency virus (HIV)–related elevated cardiovascular disease risk remain unclear. APPROACH AND RESULTS—: The associations between total plasma Lp(a) level, allele-specific apo(a) level, an Lp(a) level carried by individual apo(a) alleles, and common carotid artery intima–media thickness were assessed in 150 HIV-infected and 100 HIV-uninfected women in the WIHS (Women’s Interagency HIV Study). Linear regression analyses with and without adjustments were used. The cohort was young (mean age, ≈31 years), with the majority being Blacks (≈70%). The prevalence of a small size apo(a) (≤22 Kringle repeats) or a high Lp(a) level (≥30 mg/dL) was similar by HIV status. Total plasma Lp(a) level (P=0.029) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.022) were significantly associated with carotid artery intima–media thickness in the HIV-infected women only. After accounting for confounders (age, race, smoking, body mass index, blood pressure, hepatitis C virus coinfection, menopause, plasma lipids, treatment status, CD4 T cell count, and HIV/RNA viral load), the association remained significant for both Lp(a) (P=0.035) and allele-specific apo(a) level carried by the smaller apo(a) sizes (P=0.010) in the HIV-infected women. Notably, none of the other lipids/lipoproteins was associated with carotid artery intima–media thickness. CONCLUSIONS—: Lp(a) and allele-specific apo(a) levels predict carotid artery intima–media thickness in HIV-infected young women. Further research is needed to identify underlying mechanisms of an increased Lp(a) atherogenicity in HIV infection.

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