TY - JOUR
T1 - Lipoprotein levels and cardiovascular risk in HIV-infected and uninfected Rwandan women
AU - Anastos, Kathryn
AU - Ndamage, François
AU - Lu, Dalian
AU - Cohen, Mardge H.
AU - Shi, Qiuhu
AU - Lazar, Jason
AU - Bigirimana, Venerand
AU - Mutimura, Eugene
N1 - Funding Information:
The authors thank the study participants and staff of RWISA, especially Bosco Ndabarinze. The authors dedicate this paper to the memory of their colleague Dr. François Ndamage, RWISA Principal Investigator 2007-8. This study was supported by supplements from the National Institute of Allergy and Infectious Diseases to the Bronx/Manhattan Women’s Interagency HIV Study (WIHS), which is funded by the National Institute of Allergy and Infectious Diseases (UO1-AI-35004). This work was also supported in part by the AIDS International Training and Research Program (Fogarty International Center, NIH D43-TW001403) and the Center for AIDS Research of the Albert Einstein College of Medicine and Montefiore Medical Center funded by the National Institutes of Health (NIH AI-51519) and by the National Institute of Diabetes and Digestive and Kidney Disease (DK54615), and the Chicago WIHS (U01-AI-34993). Data in this manuscript were presented in part at the XVI International AIDS Conference, Toronto, Canada; August 13-18, 2006.
PY - 2010/8/26
Y1 - 2010/8/26
N2 - Background: Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.Methods: Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG < 400 and measured directly if TG ≥ 400 mg/dl.Results: BMI was similar in HIV+ and -negative women, < 1% were diabetic, and HIV+ women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV+ women (44 vs. 54 mg/dL, p < 0.0001) with no significant difference by CD4 count (p = 0.13). HIV serostatus (p = 0.005) and among HIV+ women lower CD4 count (p = 0.04) were associated with higher TG. BMI was independently associated with higher LDL (p = 0.01), and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were < 2% in both groups.Conclusions: In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women.
AB - Background: Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.Methods: Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG < 400 and measured directly if TG ≥ 400 mg/dl.Results: BMI was similar in HIV+ and -negative women, < 1% were diabetic, and HIV+ women were younger. In multivariate models LDL was not associated with HIV-serostatus. HDL was lower in HIV+ women (44 vs. 54 mg/dL, p < 0.0001) with no significant difference by CD4 count (p = 0.13). HIV serostatus (p = 0.005) and among HIV+ women lower CD4 count (p = 0.04) were associated with higher TG. BMI was independently associated with higher LDL (p = 0.01), and higher total body fat was strongly associated with higher total-C and LDL. Framingham risk scores were < 2% in both groups.Conclusions: In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women.
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U2 - 10.1186/1742-6405-7-34
DO - 10.1186/1742-6405-7-34
M3 - Article
C2 - 20796311
AN - SCOPUS:77956864150
SN - 1742-6405
VL - 7
JO - AIDS Research and Therapy
JF - AIDS Research and Therapy
M1 - 34
ER -