Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

R. V. Schillace; N. Pisenti; N. Pattamanuch; S. Galligan; G. H. Marracci; D. N. Bourdette; D. W. Carr

doi:10.1016/j.bbrc.2006.12.195

Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

R. V. Schillace, N. Pisenti, N. Pattamanuch, S. Galligan, G. H. Marracci, D. N. Bourdette, D. W. Carr

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells to the spinal cord. The mechanism by which this occurs is largely unknown. In this report we demonstrate that LA induces increases in cyclic AMP, a known immunosuppressant, in human T cells. The increase in cAMP is associated with increased adenylyl cyclase activity and is partially blocked by prostanoid receptor antagonists. We present evidence that LA also stimulates cAMP production in natural killer (NK) cells. This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases.

Original language	English (US)
Pages (from-to)	259-264
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2006.12.195
State	Published - Mar 2 2007
Externally published	Yes

Keywords

Lipoic acid
Lymphocyte
NK cell
cAMP

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2006.12.195

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title = "Lipoic acid stimulates cAMP production in T lymphocytes and NK cells",

abstract = "The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells to the spinal cord. The mechanism by which this occurs is largely unknown. In this report we demonstrate that LA induces increases in cyclic AMP, a known immunosuppressant, in human T cells. The increase in cAMP is associated with increased adenylyl cyclase activity and is partially blocked by prostanoid receptor antagonists. We present evidence that LA also stimulates cAMP production in natural killer (NK) cells. This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases.",

keywords = "Lipoic acid, Lymphocyte, NK cell, cAMP",

author = "Schillace, {R. V.} and N. Pisenti and N. Pattamanuch and S. Galligan and Marracci, {G. H.} and Bourdette, {D. N.} and Carr, {D. W.}",

note = "Funding Information: This research was supported by Department of Veterans Affairs Biomedical Laboratory Research & Development Service (D.W.C. and D.N.B.), by NIH Grant P50AT00066-01 (D.N.B.), and the Nancy Davis Center Without Walls (D.N.B.).",

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doi = "10.1016/j.bbrc.2006.12.195",

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AU - Schillace, R. V.

AU - Pisenti, N.

AU - Pattamanuch, N.

AU - Galligan, S.

AU - Marracci, G. H.

AU - Bourdette, D. N.

AU - Carr, D. W.

N1 - Funding Information: This research was supported by Department of Veterans Affairs Biomedical Laboratory Research & Development Service (D.W.C. and D.N.B.), by NIH Grant P50AT00066-01 (D.N.B.), and the Nancy Davis Center Without Walls (D.N.B.).

PY - 2007/3/2

Y1 - 2007/3/2

N2 - The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells to the spinal cord. The mechanism by which this occurs is largely unknown. In this report we demonstrate that LA induces increases in cyclic AMP, a known immunosuppressant, in human T cells. The increase in cAMP is associated with increased adenylyl cyclase activity and is partially blocked by prostanoid receptor antagonists. We present evidence that LA also stimulates cAMP production in natural killer (NK) cells. This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases.

AB - The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells to the spinal cord. The mechanism by which this occurs is largely unknown. In this report we demonstrate that LA induces increases in cyclic AMP, a known immunosuppressant, in human T cells. The increase in cAMP is associated with increased adenylyl cyclase activity and is partially blocked by prostanoid receptor antagonists. We present evidence that LA also stimulates cAMP production in natural killer (NK) cells. This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases.

KW - Lipoic acid

KW - Lymphocyte

KW - NK cell

KW - cAMP

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Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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