Lipid changes during the menopause transition in relation to age and weight

Carol A. Derby, Sybil L. Crawford, Richard C. Pasternak, Maryfran Sowers, Barbara Sternfeld, Karen A. Matthews

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (≥130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.

Original languageEnglish (US)
Pages (from-to)1352-1361
Number of pages10
JournalAmerican Journal of Epidemiology
Volume169
Issue number11
DOIs
StatePublished - Jun 2009

Fingerprint

Menopause
Lipids
Weights and Measures
Postmenopause
Follicle Stimulating Hormone
LDL Cholesterol
Estradiol
Lipoprotein(a)
Women's Health
HDL Cholesterol
Odds Ratio
Cholesterol
Hormones
Confidence Intervals
Hemorrhage

Keywords

  • Body weight
  • Lipids
  • Menopause

ASJC Scopus subject areas

  • Epidemiology

Cite this

Derby, C. A., Crawford, S. L., Pasternak, R. C., Sowers, M., Sternfeld, B., & Matthews, K. A. (2009). Lipid changes during the menopause transition in relation to age and weight. American Journal of Epidemiology, 169(11), 1352-1361. https://doi.org/10.1093/aje/kwp043

Lipid changes during the menopause transition in relation to age and weight. / Derby, Carol A.; Crawford, Sybil L.; Pasternak, Richard C.; Sowers, Maryfran; Sternfeld, Barbara; Matthews, Karen A.

In: American Journal of Epidemiology, Vol. 169, No. 11, 06.2009, p. 1352-1361.

Research output: Contribution to journalArticle

Derby, CA, Crawford, SL, Pasternak, RC, Sowers, M, Sternfeld, B & Matthews, KA 2009, 'Lipid changes during the menopause transition in relation to age and weight', American Journal of Epidemiology, vol. 169, no. 11, pp. 1352-1361. https://doi.org/10.1093/aje/kwp043
Derby, Carol A. ; Crawford, Sybil L. ; Pasternak, Richard C. ; Sowers, Maryfran ; Sternfeld, Barbara ; Matthews, Karen A. / Lipid changes during the menopause transition in relation to age and weight. In: American Journal of Epidemiology. 2009 ; Vol. 169, No. 11. pp. 1352-1361.
@article{a47de41475964b9f902757edf7d0d766,
title = "Lipid changes during the menopause transition in relation to age and weight",
abstract = "Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (≥130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95{\%} confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.",
keywords = "Body weight, Lipids, Menopause",
author = "Derby, {Carol A.} and Crawford, {Sybil L.} and Pasternak, {Richard C.} and Maryfran Sowers and Barbara Sternfeld and Matthews, {Karen A.}",
year = "2009",
month = "6",
doi = "10.1093/aje/kwp043",
language = "English (US)",
volume = "169",
pages = "1352--1361",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Lipid changes during the menopause transition in relation to age and weight

AU - Derby, Carol A.

AU - Crawford, Sybil L.

AU - Pasternak, Richard C.

AU - Sowers, Maryfran

AU - Sternfeld, Barbara

AU - Matthews, Karen A.

PY - 2009/6

Y1 - 2009/6

N2 - Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (≥130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.

AB - Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (≥130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.

KW - Body weight

KW - Lipids

KW - Menopause

UR - http://www.scopus.com/inward/record.url?scp=66249134613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66249134613&partnerID=8YFLogxK

U2 - 10.1093/aje/kwp043

DO - 10.1093/aje/kwp043

M3 - Article

C2 - 19357323

AN - SCOPUS:66249134613

VL - 169

SP - 1352

EP - 1361

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 11

ER -