'Linkage analysis of thyroid antibody production

Evidence for shared susceptibility to clinical autoimmune thyroid disease

Yoshiyuki Ban, David A. Greenberg, Terry F. Davies, Eric Jacobson, Erlinda Concepcion, Yaron Tomer

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Context: Epidemiological data suggest a genetic susceptibility to thyroid antibody (TAb) production. Objective: The objective of the study was to identify genetic loci that are linked with TAb production. Design: The design of the study was a whole genome linkage study in families with clustering of thyroid autoimmunity. Settings: The study took place at an academic medical center. Participants: Participants included 102 multigenerational families (540 individuals) multiplex for autoimmune thyroid disease (AITD) and TAb production. Main Outcome Measures: Wecomputed two-point logarithm of odds (LOD) scores and multipoint heterogeneity LOD scores for 400 microsatellite markers spanning the entire human genome at an average distance of 10 cm (∼10 Mb). Results: Three loci showed evidence for linkage with TAb production: 1) 2q locus, which gave a maximum multipoint heterogeneity LOD score (HLOD) of 2.8 and contained the CTLA-4 gene, previously reported to be linked and associated with clinical AITD; (2) 6p locus (HLOD 2.5), which was the same AITD-1 locus found to be linked with clinical AITD; and (3) 8q locus (HLOD 2.2), which contained the thyroglobulin gene, also previously reported to be linked and associated with AITD. All loci that were linked to TAb were also linked to AITD, suggesting that TAb and AITD share the same genetic predisposition. Conclusions: Weconclude that: 1) some of the genes/loci predisposing to TAb and AITD are shared, whereas distinct genes/loci also exist; (2) the presence of TAb in relatives of AITD patients may be associated with increased risk for the development of clinical AITD; and (3) further studies are needed to determine the predictive value of TAb levels for the development of clinical AITD in relatives of patients with familial AITD.

Original languageEnglish (US)
Pages (from-to)3589-3596
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number9
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Thyroid Diseases
Autoimmune Diseases
Antibody Formation
Thyroid Gland
Antibodies
Genes
Genetic Predisposition to Disease
Genetic Loci
Thyroglobulin
Human Genome
Autoimmunity
Microsatellite Repeats
Cluster Analysis
Outcome Assessment (Health Care)
Genome

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

'Linkage analysis of thyroid antibody production : Evidence for shared susceptibility to clinical autoimmune thyroid disease. / Ban, Yoshiyuki; Greenberg, David A.; Davies, Terry F.; Jacobson, Eric; Concepcion, Erlinda; Tomer, Yaron.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 9, 09.2008, p. 3589-3596.

Research output: Contribution to journalArticle

Ban, Yoshiyuki ; Greenberg, David A. ; Davies, Terry F. ; Jacobson, Eric ; Concepcion, Erlinda ; Tomer, Yaron. / 'Linkage analysis of thyroid antibody production : Evidence for shared susceptibility to clinical autoimmune thyroid disease. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 9. pp. 3589-3596.
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abstract = "Context: Epidemiological data suggest a genetic susceptibility to thyroid antibody (TAb) production. Objective: The objective of the study was to identify genetic loci that are linked with TAb production. Design: The design of the study was a whole genome linkage study in families with clustering of thyroid autoimmunity. Settings: The study took place at an academic medical center. Participants: Participants included 102 multigenerational families (540 individuals) multiplex for autoimmune thyroid disease (AITD) and TAb production. Main Outcome Measures: Wecomputed two-point logarithm of odds (LOD) scores and multipoint heterogeneity LOD scores for 400 microsatellite markers spanning the entire human genome at an average distance of 10 cm (∼10 Mb). Results: Three loci showed evidence for linkage with TAb production: 1) 2q locus, which gave a maximum multipoint heterogeneity LOD score (HLOD) of 2.8 and contained the CTLA-4 gene, previously reported to be linked and associated with clinical AITD; (2) 6p locus (HLOD 2.5), which was the same AITD-1 locus found to be linked with clinical AITD; and (3) 8q locus (HLOD 2.2), which contained the thyroglobulin gene, also previously reported to be linked and associated with AITD. All loci that were linked to TAb were also linked to AITD, suggesting that TAb and AITD share the same genetic predisposition. Conclusions: Weconclude that: 1) some of the genes/loci predisposing to TAb and AITD are shared, whereas distinct genes/loci also exist; (2) the presence of TAb in relatives of AITD patients may be associated with increased risk for the development of clinical AITD; and (3) further studies are needed to determine the predictive value of TAb levels for the development of clinical AITD in relatives of patients with familial AITD.",
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