Abstract
Background Individuals ineligible for interferon-based hepatitis C therapy may have a worse prognosis than patients who have failed or not received treatment. Aims To provide information about the limitations of medical treatment of hepatitis C in real-world patients. Methods We studied 969 treatment-ineligible patients and 403 treated patients enrolled between 1/1/01 and 6/30/06; data were collected until 3/31/13. Treatment barriers were grouped into five categories and classified as health-related or health-unrelated. Fibrosis stage was assessed initially and at the end of follow-up. Mortality was determined by search of the Social Security database. Death certificates of treatment-ineligible patients were reviewed. Results Initially, 288 individuals had advanced fibrosis and compensated disease; 87 untreated patients developed advanced fibrosis during follow-up. Health-related treatment barriers were more commonly associated with fibrosis progression and worse survival. During follow-up, 247 untreated patients died: 47% of liver-related and 53% of liver-unrelated causes. Patients with significant comorbid illness had the worst five- (70%) and ten-year (50.5%) survival. Despite high mortality (47%) in persons with decompensated liver disease, no treatment barrier was associated with a greater incidence of liver-related death. Only significant comorbid medical illness was an independent predictor of disease progression; however, it was not associated with a greater incidence of liver-related death. Furthermore, treated patients had better 10-year survival than untreated patients on Kaplan–Meier analysis (80.3% vs. 74.5%, P = 0.005). Conclusion Many patients with hepatitis C will die of non-liver-related causes and may not be helped by anti-viral treatment.
Original language | English (US) |
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Pages (from-to) | 100-108 |
Number of pages | 9 |
Journal | Journal of Clinical and Experimental Hepatology |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2016 |
Keywords
- hepatitis C
- liver fibrosis
- mortality
- progression
- treatment barrier
ASJC Scopus subject areas
- Hepatology