TY - JOUR
T1 - Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP diet and health study
AU - Kabat, Geoffrey C.
AU - Wu, Jennifer W.
AU - Moore, Steven C.
AU - Morton, Lindsay M.
AU - Park, Yikyung
AU - Hollenbeck, Albert R.
AU - Rohan, Thomas E.
PY - 2013/5
Y1 - 2013/5
N2 - Background: Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population. Methods:Weexamined the relation between lifestyle and dietary risk factors forCMLin 493,188 participants (294,271 males and 198,917 females) aged 50 to 71 years who completed a baseline questionnaire in the National Institutes of Health-AARP Diet and Health Study in 1995 to 1996. Over a median of 10.5 years of follow-up, 178 incident cases of CML (139 males and 39 females) were ascertained from state registries. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for exposures of interest, adjusting for potential confounding variables. Results: In multivariable analysis of all participants combined, female sex, years of education, and vigorous physical activity (HR for >3 times/week vs. <1 time/week 0.70; 95% CI, 0.49-0.99) were inversely associated with risk of CML, whereas smoking intensity (HR for smokers of-20 cigarettes per day vs. never smokers: 1.53; 95% CI, 1.03-2.27) and body mass (HR for BMI>30 vs. <25 kg/m2 1.46; 95% CI, 0.95-2.23) were associated with increased risk. A range of dietary factors was not associated with disease. Conclusions: This study adds to the sparse information about lifestyle factors, which affect the risk of CML in the general population. Impact: If these findings are confirmed, it would suggest thatCMLmaybe amenable to preventive strategies. Cancer Epidemiol Biomarkers Prev; 22(5); 848-54.
AB - Background: Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population. Methods:Weexamined the relation between lifestyle and dietary risk factors forCMLin 493,188 participants (294,271 males and 198,917 females) aged 50 to 71 years who completed a baseline questionnaire in the National Institutes of Health-AARP Diet and Health Study in 1995 to 1996. Over a median of 10.5 years of follow-up, 178 incident cases of CML (139 males and 39 females) were ascertained from state registries. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for exposures of interest, adjusting for potential confounding variables. Results: In multivariable analysis of all participants combined, female sex, years of education, and vigorous physical activity (HR for >3 times/week vs. <1 time/week 0.70; 95% CI, 0.49-0.99) were inversely associated with risk of CML, whereas smoking intensity (HR for smokers of-20 cigarettes per day vs. never smokers: 1.53; 95% CI, 1.03-2.27) and body mass (HR for BMI>30 vs. <25 kg/m2 1.46; 95% CI, 0.95-2.23) were associated with increased risk. A range of dietary factors was not associated with disease. Conclusions: This study adds to the sparse information about lifestyle factors, which affect the risk of CML in the general population. Impact: If these findings are confirmed, it would suggest thatCMLmaybe amenable to preventive strategies. Cancer Epidemiol Biomarkers Prev; 22(5); 848-54.
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U2 - 10.1158/1055-9965.EPI-13-0093
DO - 10.1158/1055-9965.EPI-13-0093
M3 - Article
C2 - 23625904
AN - SCOPUS:84877967192
SN - 1055-9965
VL - 22
SP - 848
EP - 854
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -
