Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated

T. Kato, T. Katagiri, A. Hirano, T. Kawanami, H. Sasaki

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Abstract

Round eosinophilic hyaline inclusion bodies with halos in the somata of anterior horn cells from a case of sporadic lower motor neuron disease (MND) were intensely immunostained with the monoclonal anti-ubiquitin antibody (DF2). A few similar, DF2-positive inclusions were also observed in the nerve cell processes of anterior horn cells or in the neuropil. Most inclusions showed intense homogeneous staining of the entire inclusion, whereas a few had intense staining of their periphery with no or pale staining of the central areas. Other DF2-positive structures in the somata of anterior horn cells included cytoplasmic granular structures, eosinophilic thread-like or reticular structures, and small eosinophilic profiles different from Bunina bodies. The DF2-staining intensity of Bunina bodies and spheroids did not exceed the background level. These results suggest that ubiquitination is associated with a pathological process of anterior horn cell degeneration in this MND case.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalActa neuropathologica
Volume77
Issue number4
DOIs
Publication statusPublished - Jul 1 1989

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Keywords

  • Bunina body
  • Hyaline inclusion body
  • Lewy body like inclusion
  • Sporadic motor neuron disease
  • Ubiquitin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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