Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated

T. Kato, T. Katagiri, A. Hirano, T. Kawanami, H. Sasaki

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Round eosinophilic hyaline inclusion bodies with halos in the somata of anterior horn cells from a case of sporadic lower motor neuron disease (MND) were intensely immunostained with the monoclonal anti-ubiquitin antibody (DF2). A few similar, DF2-positive inclusions were also observed in the nerve cell processes of anterior horn cells or in the neuropil. Most inclusions showed intense homogeneous staining of the entire inclusion, whereas a few had intense staining of their periphery with no or pale staining of the central areas. Other DF2-positive structures in the somata of anterior horn cells included cytoplasmic granular structures, eosinophilic thread-like or reticular structures, and small eosinophilic profiles different from Bunina bodies. The DF2-staining intensity of Bunina bodies and spheroids did not exceed the background level. These results suggest that ubiquitination is associated with a pathological process of anterior horn cell degeneration in this MND case.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalActa Neuropathologica
Volume77
Issue number4
DOIs
StatePublished - Jul 1989

Fingerprint

Anterior Horn Cells
Lewy Bodies
Motor Neuron Disease
Hyalin
Staining and Labeling
Carisoprodol
Cytoplasmic Structures
Neuropil
Ubiquitination
Inclusion Bodies
Pathologic Processes
Ubiquitin
Anti-Idiotypic Antibodies
Monoclonal Antibodies
Neurons

Keywords

  • Bunina body
  • Hyaline inclusion body
  • Lewy body like inclusion
  • Sporadic motor neuron disease
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated. / Kato, T.; Katagiri, T.; Hirano, A.; Kawanami, T.; Sasaki, H.

In: Acta Neuropathologica, Vol. 77, No. 4, 07.1989, p. 391-396.

Research output: Contribution to journalArticle

Kato, T, Katagiri, T, Hirano, A, Kawanami, T & Sasaki, H 1989, 'Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated', Acta Neuropathologica, vol. 77, no. 4, pp. 391-396. https://doi.org/10.1007/BF00687373
Kato, T. ; Katagiri, T. ; Hirano, A. ; Kawanami, T. ; Sasaki, H. / Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated. In: Acta Neuropathologica. 1989 ; Vol. 77, No. 4. pp. 391-396.
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