Leucocytes and Free Radicals in Stable Angina Pectoris

Giovanni Ciuffetti, Luigi Corea, Elmo Mannarino, Michele Mercuri, Rita Lombardini, Laura Santambrogio

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Bicycle ergometer exercise was used to induce ischemia in 20 patients with stable angina pectoris (SAP). Superoxide dismutase (SOD) blood concentrations, free radical generation (by the SOD-inhibitable reaction of ferricytochrome C), malondialdehyde (MDA) plasma concentrations, the unfractionated leucocyte filterability rate and the filterability rates of the granulocyte and mononuclear sub-fractions (using a positive pressure filtration system and 5 μ diameter Nuclepore filters), were monitored before and after exercise in the patients and in 18 matched controls. At the onset of ischemia a significant increase in the level of MDA plasma concentrations and significant decreases in both SOD blood concentrations and the SOD-inhibitable reduction of ferricytochrome G indicated oxygen free radicals had been released in the SAP patients. These changes were associated with significant impairments of granulocyte and unfractionated leucocyte filterabilities and with morphological evidence of granulocyte activation.

Original languageEnglish (US)
Pages (from-to)145-157
Number of pages13
JournalJapanese Heart Journal
Issue number2
StatePublished - 1992


  • Exercise
  • Ischemia
  • Oxygen free radicals
  • Stable angina pectoris

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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