Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides

R. Wieczorek, Mark J. Suhrland, D. Ramsay, M. L. Reed, D. M. Knowles

Research output: Contribution to journalArticle

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Abstract

The authors describe two patients with clinically and histopathologically documented advanced (tumor) stage mycosis fungoides. In each case the large, pleomorphic neoplastic cells lacked the monoclonal antibody-defined cell surface antigens commonly associated with immature and mature T-cells, i.e., T11, Leu-1, T3, T4, T6, T8, and T10, but expressed various T-cell-associated activation antigens, such as HLA-DR, Tac, and T21. Leu-M1, a monocyte-associated antigen, was not expressed by the small, cerebriform neoplastic cells in the plaque stage lesions of either patient. However, Leu-M1 was expressed by most of the large, pleomorphic neoplastic cells present in the nodular lesions of both patients. The pattern of Leu-M1 antigen expression was identical to that previously reported in the Reed-Sternberg cells of Hodgkin's disease. Identification of these two patients suggests using caution in the interpretation of the results of immunophenotypic analysis of cutaneous lymphoid neoplasms and that Leu-M1 should not be used as a diagnostic indicator of Hodgkin's disease or a histiocytic-derived neoplasm. These studies also suggest that Leu-M1 may be preferentially expressed on a subpopulation of activated, rapidly proliferating, and/or dedifferentiated neoplastic T-cells that proliferate in the advanced (tumor) stages of mycosis fungoides.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume86
Issue number1
StatePublished - 1986
Externally publishedYes

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Mycosis Fungoides
Hodgkin Disease
Neoplasms
CD27 Antigens
Reed-Sternberg Cells
T-Lymphocytes
HLA-DR Antigens
Skin Neoplasms
Surface Antigens
Monocytes
Monoclonal Antibodies
Antigens
Leu-M1 antigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Wieczorek, R., Suhrland, M. J., Ramsay, D., Reed, M. L., & Knowles, D. M. (1986). Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides. American Journal of Clinical Pathology, 86(1), 25-32.

Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides. / Wieczorek, R.; Suhrland, Mark J.; Ramsay, D.; Reed, M. L.; Knowles, D. M.

In: American Journal of Clinical Pathology, Vol. 86, No. 1, 1986, p. 25-32.

Research output: Contribution to journalArticle

Wieczorek, R, Suhrland, MJ, Ramsay, D, Reed, ML & Knowles, DM 1986, 'Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides', American Journal of Clinical Pathology, vol. 86, no. 1, pp. 25-32.
Wieczorek, R. ; Suhrland, Mark J. ; Ramsay, D. ; Reed, M. L. ; Knowles, D. M. / Leu-M1 antigen expression in advanced (tumor) stage mycosis fungoides. In: American Journal of Clinical Pathology. 1986 ; Vol. 86, No. 1. pp. 25-32.
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