Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

Daniel Zamith-Miranda, Lysangela Ronalte Alves, Ernesto Satoshi Nakayasu, Joshua Daniel Nosanchuk

Research output: Contribution to journalArticlepeer-review


Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCurrent Topics in Microbiology and Immunology
StatePublished - 2021


  • Extracellular vesicles
  • Histoplasma capsulatum
  • Proteomics
  • Serology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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