Lessons from genetically engineered animal models VI. Liver repopulation systems and study of pathophysiological mechanisms in animals

Sanjeev Gupta, Charles E. Rogler

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The ability to localize transplanted hepatocytes in the liver offers exciting new opportunities. Transplanted hepatocytes enter liver plates, form hybrid plasma membrane structures with adjacent hepatocytes, express liver genes correctly, and survive indefinitely. The transplanted cell mass is regulated, such that cell proliferation is limited in the normal adult liver, whereas the liver is repopulated extensively when proliferation rates in transplanted and host hepatocytes become dissociated or host hepatocytes are ablated selectively. Transplanted hepatocytes are susceptible to hepatitis viruses. These aspects of transplanted hepatocyte biology indicate that liver repopulation systems can help address questions concerning pathophysiological mechanisms.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume277
Issue number6 40-6
StatePublished - Dec 1999

Fingerprint

Genetically Modified Animals
Hepatocytes
Animal Models
Liver
Hepatitis Viruses
Cell Proliferation
Cell Membrane
Genes

Keywords

  • Hepatitis B virus
  • Hepatocyte
  • Transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Physiology (medical)

Cite this

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