Leptin receptor modulation of adiposity and fertility

Davelene Israel, Streamson C. Chua, Jr.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The leptin receptor was discovered as a leptin binding protein, which is highly expressed in the choroid plexus. Mapping of the gene's chromosomal locations in rodents revealed that mutations in Lepr were the basis of obesity/diabetes mutations in rodents and humans. Genetic manipulations that target Lepr expression in specific neurons or hypothalamic areas have generated insights into the modes by which body composition and reproductive function are modulated by the leptin receptor. These animal models have also been instrumental in identifying diabetes susceptibility genes. In this review we discuss the evidence that supports the concept of networked functions of leptin receptor as it pertains to feeding, substrate utilization and reproduction.

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Leptin Receptors
Adiposity
Fertility
Rodentia
Mutation
Choroid Plexus
Chromosome Mapping
Body Composition
Reproduction
Animal Models
Obesity
Neurons
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Leptin receptor modulation of adiposity and fertility. / Israel, Davelene; Chua, Jr., Streamson C.

In: Trends in Endocrinology and Metabolism, Vol. 21, No. 1, 01.2010, p. 10-16.

Research output: Contribution to journalArticle

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