Abstract
Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differences contribute to the phenotypic behaviors of leptin-deficient ob/ob mice, and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Basal striatal D2R binding (measured with autoradiography [3H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.
Original language | English (US) |
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Pages (from-to) | 503-510 |
Number of pages | 8 |
Journal | Synapse |
Volume | 64 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2010 |
Externally published | Yes |
Keywords
- Autoradiography
- B-imager
- Food
- Insulin
- Obesity
- Reward
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience