Lens development and crystallin gene expression: Many roles for Pax-6

Ales Cvekl, Joram Piatigorsky

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

The vertebrate eye lens has been used extensively as a model for developmental processes such as determination, embryonic induction, cellular differentiation, transdifferentiation and regeneration, with the crystallin genes being a prime example of developmentally controlled, tissue- preferred gene expression. Recent studies have shown that Pax-6, a transcription factor containing both a paired domain and homeodomain, is a key protein regulating lens determination and crystallin gene expression in the lens. The use of Pax-6 for expression of different crystallin genes provides a new link at the developmental and transcriptional level among the diverse crystallins and may lead to new insights into their evolutionary recruitment as refractive proteins.

Original languageEnglish (US)
Pages (from-to)621-630
Number of pages10
JournalBioEssays
Volume18
Issue number8
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

crystallins
Crystallins
Lens
Gene expression
Lenses
Gene Expression
gene expression
Genes
eye lens
Embryonic Induction
Crystalline Lens
Proteins
Transcription Factors
genes
transcription factors
proteins
vertebrates
Vertebrates
Tissue
Regeneration

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Lens development and crystallin gene expression : Many roles for Pax-6. / Cvekl, Ales; Piatigorsky, Joram.

In: BioEssays, Vol. 18, No. 8, 08.1996, p. 621-630.

Research output: Contribution to journalArticle

Cvekl, A & Piatigorsky, J 1996, 'Lens development and crystallin gene expression: Many roles for Pax-6', BioEssays, vol. 18, no. 8, pp. 621-630.
Cvekl, Ales ; Piatigorsky, Joram. / Lens development and crystallin gene expression : Many roles for Pax-6. In: BioEssays. 1996 ; Vol. 18, No. 8. pp. 621-630.
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