Lens development and crystallin gene expression: Many roles for Pax-6

Aleš Cvekl, Joram Piatigorsky

Research output: Contribution to journalReview article

239 Scopus citations

Abstract

The vertebrate eye lens has been used extensively as a model for developmental processes such as determination, embryonic induction, cellular differentiation, transdifferentiation and regeneration, with the crystallin genes being a prime example of developmentally controlled, tissue- preferred gene expression. Recent studies have shown that Pax-6, a transcription factor containing both a paired domain and homeodomain, is a key protein regulating lens determination and crystallin gene expression in the lens. The use of Pax-6 for expression of different crystallin genes provides a new link at the developmental and transcriptional level among the diverse crystallins and may lead to new insights into their evolutionary recruitment as refractive proteins.

Original languageEnglish (US)
Pages (from-to)621-630
Number of pages10
JournalBioEssays
Volume18
Issue number8
DOIs
StatePublished - Aug 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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