Lens Development and Crystallin Gene Expression

Ales Cvekl, Rebecca S. Estrada, Wei Liu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The eye and lens represent excellent models to understand embryonic development at cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal invagination of the lens placode/optic vesicle to form the eye primordium, i.e., the optic cup partially surrounding the lens vesicle. Subsequently, the anterior part of the lens vesicle gives rise to the lens epithelium, while the posterior cells of the lens vesicle differentiate into highly elongated lens fibers. Lens fiber differentiation involves cytoskeletal rearrangements, cellular elongation, accumulation of crystallin proteins, production of extracellular matrix for the lens capsule, and degradation of organelles. This chapter summarizes recent advances in lens development and provides insights into the regulatory mechanisms and differentiation at the level of chromatin structure and dynamics, the emerging field of noncoding RNAs, and novel strategies to fill the gaps in our understanding of lens development.

Original languageEnglish (US)
Pages (from-to)129-167
Number of pages39
JournalProgress in Molecular Biology and Translational Science
Volume134
DOIs
StatePublished - 2015

Fingerprint

Crystallins
Lenses
Gene Expression
Untranslated RNA
Crystalline Lens
Extracellular Matrix Proteins
Organelles
Chromatin
Capsules
Embryonic Development
Epithelium

Keywords

  • BMP
  • c-Maf
  • Crystallin
  • Differentiation
  • FGF
  • Hsf4
  • Lens
  • Pax6
  • Six3
  • Sox2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lens Development and Crystallin Gene Expression. / Cvekl, Ales; Estrada, Rebecca S.; Liu, Wei.

In: Progress in Molecular Biology and Translational Science, Vol. 134, 2015, p. 129-167.

Research output: Contribution to journalArticle

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