Leg ulcers in sickle cell disease

Caterina P. Minniti, James Eckman, Paola Sebastiani, Martin H. Steinberg, Samir K. Ballas

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. The manifestations of this disease are protean. Among them, leg ulcers represent a particularly disabling and chronic complication, often associated with a more severe clinical course. Despite the fact that this complication has been recognized since the early times of SCD, there has been little improvement in the efficacy of its management and clinical outcome over the past 100 years. Recently, vasculopathic abnormalities involving abnormal vascular tone and activated, adhesive endothelium have been recognized as another pathway to end organ damage in sickle cell disease. Vasculopathy of sickle cell disease has been implicated in the development of pulmonary hypertension, stroke, leg ulceration and priapism, particularly associated with hemolytic severity, and reported in other severe hemolytic disorders. The authors present the proceedings from the Educational Session on Chronic leg ulcers in Sickle cell disease, held during the 4th Annual Sickle Cell Disease Research and Educational Symposium, on February 17, 2010 in Fort Lauderdale, Fla.

Original languageEnglish (US)
Pages (from-to)831-833
Number of pages3
JournalAmerican Journal of Hematology
Volume85
Issue number10
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Leg Ulcer
Sickle Cell Anemia
Priapism
Pulmonary Hypertension
Polymerization
Adhesives
Infarction
Endothelium
Blood Vessels
Leg
Hemoglobins
Ischemia
Stroke
Amino Acids
Research

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Minniti, C. P., Eckman, J., Sebastiani, P., Steinberg, M. H., & Ballas, S. K. (2010). Leg ulcers in sickle cell disease. American Journal of Hematology, 85(10), 831-833. https://doi.org/10.1002/ajh.21838

Leg ulcers in sickle cell disease. / Minniti, Caterina P.; Eckman, James; Sebastiani, Paola; Steinberg, Martin H.; Ballas, Samir K.

In: American Journal of Hematology, Vol. 85, No. 10, 2010, p. 831-833.

Research output: Contribution to journalArticle

Minniti, CP, Eckman, J, Sebastiani, P, Steinberg, MH & Ballas, SK 2010, 'Leg ulcers in sickle cell disease', American Journal of Hematology, vol. 85, no. 10, pp. 831-833. https://doi.org/10.1002/ajh.21838
Minniti CP, Eckman J, Sebastiani P, Steinberg MH, Ballas SK. Leg ulcers in sickle cell disease. American Journal of Hematology. 2010;85(10):831-833. https://doi.org/10.1002/ajh.21838
Minniti, Caterina P. ; Eckman, James ; Sebastiani, Paola ; Steinberg, Martin H. ; Ballas, Samir K. / Leg ulcers in sickle cell disease. In: American Journal of Hematology. 2010 ; Vol. 85, No. 10. pp. 831-833.
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