Left ventricular remodelling and vascular adaptive changes in adolescents with obesity

A. Kulkarni, T. Gulesserian, J. M.M.D. Lorenzo, Y. Haroonian, M. Ngyuyen, Yungtai Lo, D. Wang, D. Hsu, Frederick J. Kaskel, Joseph Mahgerefteh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of this study was to determine the effects of obesity on myocardial mechanics and ventriculo-arterial coupling (V-A) in children. Methods: Strain parameters, stroke volume, arterial elastance, left ventricular (LV) elastance and V-A were compared after adjusting for age and hypertension and after multivariate sub-group analysis between patients with and without obesity. Results: Among 123 retrospectively enrolled subjects, 6-21 years age, 79.7% males, 52% were obese. Median (range) Body Mass Index Z score was +2.35 (1.67-4.43) for obese and +0.68 (-2.48-1.63) for non-obese. Subjects with obesity had higher LV mass indexed2.7 (LVMI2.7) compared with non-obese (P < 0.001). Lower global longitudinal strain (GLS) (P = 0.012), global circumferential strain (GCS) (P = 0.004), average longitudinal strain rate (P = 0.002) and average circumferential strain rate (P < 0.001) were seen in subjects with obesity; no difference was noted in arterial elastance, LV end systolic elastance and V-A. Increased LVMI2.7, decreased GLS, GCS, average longitudinal strain rate, average circumferential strain rate and maintained V-A were noted in the multivariate analysis between subgroups. Conclusions: Obesity causes alterations in myocardial mechanics with preserved V-A in children. These findings may aid intervention in preventing the long-term cadiovascular effects of obesity.

Original languageEnglish (US)
JournalPediatric obesity
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Ventricular Remodeling
Pediatric Obesity
Blood Vessels
Obesity
Mechanics
Stroke Volume
Body Mass Index
Multivariate Analysis
Hypertension

Keywords

  • Children
  • Echocardiography
  • Obesity
  • Strain
  • Ventriculo-arterial coupling

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Left ventricular remodelling and vascular adaptive changes in adolescents with obesity. / Kulkarni, A.; Gulesserian, T.; Lorenzo, J. M.M.D.; Haroonian, Y.; Ngyuyen, M.; Lo, Yungtai; Wang, D.; Hsu, D.; Kaskel, Frederick J.; Mahgerefteh, Joseph.

In: Pediatric obesity, 01.01.2018.

Research output: Contribution to journalArticle

Kulkarni, A. ; Gulesserian, T. ; Lorenzo, J. M.M.D. ; Haroonian, Y. ; Ngyuyen, M. ; Lo, Yungtai ; Wang, D. ; Hsu, D. ; Kaskel, Frederick J. ; Mahgerefteh, Joseph. / Left ventricular remodelling and vascular adaptive changes in adolescents with obesity. In: Pediatric obesity. 2018.
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abstract = "Background: The aim of this study was to determine the effects of obesity on myocardial mechanics and ventriculo-arterial coupling (V-A) in children. Methods: Strain parameters, stroke volume, arterial elastance, left ventricular (LV) elastance and V-A were compared after adjusting for age and hypertension and after multivariate sub-group analysis between patients with and without obesity. Results: Among 123 retrospectively enrolled subjects, 6-21 years age, 79.7{\%} males, 52{\%} were obese. Median (range) Body Mass Index Z score was +2.35 (1.67-4.43) for obese and +0.68 (-2.48-1.63) for non-obese. Subjects with obesity had higher LV mass indexed2.7 (LVMI2.7) compared with non-obese (P < 0.001). Lower global longitudinal strain (GLS) (P = 0.012), global circumferential strain (GCS) (P = 0.004), average longitudinal strain rate (P = 0.002) and average circumferential strain rate (P < 0.001) were seen in subjects with obesity; no difference was noted in arterial elastance, LV end systolic elastance and V-A. Increased LVMI2.7, decreased GLS, GCS, average longitudinal strain rate, average circumferential strain rate and maintained V-A were noted in the multivariate analysis between subgroups. Conclusions: Obesity causes alterations in myocardial mechanics with preserved V-A in children. These findings may aid intervention in preventing the long-term cadiovascular effects of obesity.",
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AU - Gulesserian, T.

AU - Lorenzo, J. M.M.D.

AU - Haroonian, Y.

AU - Ngyuyen, M.

AU - Lo, Yungtai

AU - Wang, D.

AU - Hsu, D.

AU - Kaskel, Frederick J.

AU - Mahgerefteh, Joseph

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N2 - Background: The aim of this study was to determine the effects of obesity on myocardial mechanics and ventriculo-arterial coupling (V-A) in children. Methods: Strain parameters, stroke volume, arterial elastance, left ventricular (LV) elastance and V-A were compared after adjusting for age and hypertension and after multivariate sub-group analysis between patients with and without obesity. Results: Among 123 retrospectively enrolled subjects, 6-21 years age, 79.7% males, 52% were obese. Median (range) Body Mass Index Z score was +2.35 (1.67-4.43) for obese and +0.68 (-2.48-1.63) for non-obese. Subjects with obesity had higher LV mass indexed2.7 (LVMI2.7) compared with non-obese (P < 0.001). Lower global longitudinal strain (GLS) (P = 0.012), global circumferential strain (GCS) (P = 0.004), average longitudinal strain rate (P = 0.002) and average circumferential strain rate (P < 0.001) were seen in subjects with obesity; no difference was noted in arterial elastance, LV end systolic elastance and V-A. Increased LVMI2.7, decreased GLS, GCS, average longitudinal strain rate, average circumferential strain rate and maintained V-A were noted in the multivariate analysis between subgroups. Conclusions: Obesity causes alterations in myocardial mechanics with preserved V-A in children. These findings may aid intervention in preventing the long-term cadiovascular effects of obesity.

AB - Background: The aim of this study was to determine the effects of obesity on myocardial mechanics and ventriculo-arterial coupling (V-A) in children. Methods: Strain parameters, stroke volume, arterial elastance, left ventricular (LV) elastance and V-A were compared after adjusting for age and hypertension and after multivariate sub-group analysis between patients with and without obesity. Results: Among 123 retrospectively enrolled subjects, 6-21 years age, 79.7% males, 52% were obese. Median (range) Body Mass Index Z score was +2.35 (1.67-4.43) for obese and +0.68 (-2.48-1.63) for non-obese. Subjects with obesity had higher LV mass indexed2.7 (LVMI2.7) compared with non-obese (P < 0.001). Lower global longitudinal strain (GLS) (P = 0.012), global circumferential strain (GCS) (P = 0.004), average longitudinal strain rate (P = 0.002) and average circumferential strain rate (P < 0.001) were seen in subjects with obesity; no difference was noted in arterial elastance, LV end systolic elastance and V-A. Increased LVMI2.7, decreased GLS, GCS, average longitudinal strain rate, average circumferential strain rate and maintained V-A were noted in the multivariate analysis between subgroups. Conclusions: Obesity causes alterations in myocardial mechanics with preserved V-A in children. These findings may aid intervention in preventing the long-term cadiovascular effects of obesity.

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