Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization

Thomas S. Maldonado, David Dexter, Caron B. Rockman, Frank J. Veith, Karan Garg, Frank Arko, Hernan Bertoni, Sharif Ellozy, William Jordan, Edward Woo

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Objective: This study assessed the risk of left subclavian artery (LSA) coverage and the role of revascularization in a large population of patients undergoing thoracic endovascular aortic aneurysm repair. Methods: A retrospective multicenter review of 1189 patient records from 2000 to 2010 was performed. Major adverse events evaluated included cerebrovascular accident (CVA) and spinal cord ischemia (SCI). Subgroup analysis was performed for noncovered LSA (group A), covered LSA (group B), and covered/revascularized LSA (group C). Results: Of 1189 patients, 394 had LSA coverage (33.1%), and 180 of these patients (46%) underwent LSA revascularization. In all patients, emergency operations (9.5% vs 4.3%; P =.001), renal failure (12.7% vs 5.3%; P =.001), hypertension (7% vs 2.3%; P =.01), and number of stents placed (1 = 3.7%, 2 = 7.4%, ≥3 = 10%; P =.005) were predictors of SCI. History of cerebrovascular disease (9.6% vs 3.5%; P =.002), chronic obstructive pulmonary disease (9.5% vs 5.4%; P =.01), coronary artery disease (8.5% vs 5.3%; P =.03), smoking (8.9% vs 4.2%) and female gender (5.3% men vs 8.2% women; P =.05) were predictors of CVA. Subgroup analysis showed no significant difference between groups B and C (SCI, 6.3% vs 6.1%; CVA, 6.7% vs 6.1%). LSA revascularization was not protective for SCI (7.5% vs 4.1%; P =.3) or CVA (6.1% vs 6.4%; P =.9). Women who underwent revascularization had an increased incidence of CVA event compared with all other subgroups (group A: 5.6% men, 8.4% women, P =.16; group B: 6.6% men, 5.3% women, P =.9; group C: 2.8% men, 11.9% women, P =.03). Conclusions: LSA coverage does not appear to result in an increased incidence of SCI or CVA event when a strategy of selective revascularization is adopted. Selective LSA revascularization results in similar outcomes among the three cohorts studied. Revascularization in women carries an increased risk of a CVA event and should be reserved for select cases.

Original languageEnglish (US)
Pages (from-to)116-124
Number of pages9
JournalJournal of Vascular Surgery
Volume57
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

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Thoracic Aortic Aneurysm
Subclavian Artery
Spinal Cord Ischemia
Stroke
Cerebrovascular Disorders
Incidence
Chronic Obstructive Pulmonary Disease
Stents
Renal Insufficiency
Coronary Artery Disease
Emergencies
Smoking
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization. / Maldonado, Thomas S.; Dexter, David; Rockman, Caron B.; Veith, Frank J.; Garg, Karan; Arko, Frank; Bertoni, Hernan; Ellozy, Sharif; Jordan, William; Woo, Edward.

In: Journal of Vascular Surgery, Vol. 57, No. 1, 01.2013, p. 116-124.

Research output: Contribution to journalArticle

Maldonado, TS, Dexter, D, Rockman, CB, Veith, FJ, Garg, K, Arko, F, Bertoni, H, Ellozy, S, Jordan, W & Woo, E 2013, 'Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization', Journal of Vascular Surgery, vol. 57, no. 1, pp. 116-124. https://doi.org/10.1016/j.jvs.2012.06.101
Maldonado, Thomas S. ; Dexter, David ; Rockman, Caron B. ; Veith, Frank J. ; Garg, Karan ; Arko, Frank ; Bertoni, Hernan ; Ellozy, Sharif ; Jordan, William ; Woo, Edward. / Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization. In: Journal of Vascular Surgery. 2013 ; Vol. 57, No. 1. pp. 116-124.
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abstract = "Objective: This study assessed the risk of left subclavian artery (LSA) coverage and the role of revascularization in a large population of patients undergoing thoracic endovascular aortic aneurysm repair. Methods: A retrospective multicenter review of 1189 patient records from 2000 to 2010 was performed. Major adverse events evaluated included cerebrovascular accident (CVA) and spinal cord ischemia (SCI). Subgroup analysis was performed for noncovered LSA (group A), covered LSA (group B), and covered/revascularized LSA (group C). Results: Of 1189 patients, 394 had LSA coverage (33.1{\%}), and 180 of these patients (46{\%}) underwent LSA revascularization. In all patients, emergency operations (9.5{\%} vs 4.3{\%}; P =.001), renal failure (12.7{\%} vs 5.3{\%}; P =.001), hypertension (7{\%} vs 2.3{\%}; P =.01), and number of stents placed (1 = 3.7{\%}, 2 = 7.4{\%}, ≥3 = 10{\%}; P =.005) were predictors of SCI. History of cerebrovascular disease (9.6{\%} vs 3.5{\%}; P =.002), chronic obstructive pulmonary disease (9.5{\%} vs 5.4{\%}; P =.01), coronary artery disease (8.5{\%} vs 5.3{\%}; P =.03), smoking (8.9{\%} vs 4.2{\%}) and female gender (5.3{\%} men vs 8.2{\%} women; P =.05) were predictors of CVA. Subgroup analysis showed no significant difference between groups B and C (SCI, 6.3{\%} vs 6.1{\%}; CVA, 6.7{\%} vs 6.1{\%}). LSA revascularization was not protective for SCI (7.5{\%} vs 4.1{\%}; P =.3) or CVA (6.1{\%} vs 6.4{\%}; P =.9). Women who underwent revascularization had an increased incidence of CVA event compared with all other subgroups (group A: 5.6{\%} men, 8.4{\%} women, P =.16; group B: 6.6{\%} men, 5.3{\%} women, P =.9; group C: 2.8{\%} men, 11.9{\%} women, P =.03). Conclusions: LSA coverage does not appear to result in an increased incidence of SCI or CVA event when a strategy of selective revascularization is adopted. Selective LSA revascularization results in similar outcomes among the three cohorts studied. Revascularization in women carries an increased risk of a CVA event and should be reserved for select cases.",
author = "Maldonado, {Thomas S.} and David Dexter and Rockman, {Caron B.} and Veith, {Frank J.} and Karan Garg and Frank Arko and Hernan Bertoni and Sharif Ellozy and William Jordan and Edward Woo",
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T1 - Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization

AU - Maldonado, Thomas S.

AU - Dexter, David

AU - Rockman, Caron B.

AU - Veith, Frank J.

AU - Garg, Karan

AU - Arko, Frank

AU - Bertoni, Hernan

AU - Ellozy, Sharif

AU - Jordan, William

AU - Woo, Edward

PY - 2013/1

Y1 - 2013/1

N2 - Objective: This study assessed the risk of left subclavian artery (LSA) coverage and the role of revascularization in a large population of patients undergoing thoracic endovascular aortic aneurysm repair. Methods: A retrospective multicenter review of 1189 patient records from 2000 to 2010 was performed. Major adverse events evaluated included cerebrovascular accident (CVA) and spinal cord ischemia (SCI). Subgroup analysis was performed for noncovered LSA (group A), covered LSA (group B), and covered/revascularized LSA (group C). Results: Of 1189 patients, 394 had LSA coverage (33.1%), and 180 of these patients (46%) underwent LSA revascularization. In all patients, emergency operations (9.5% vs 4.3%; P =.001), renal failure (12.7% vs 5.3%; P =.001), hypertension (7% vs 2.3%; P =.01), and number of stents placed (1 = 3.7%, 2 = 7.4%, ≥3 = 10%; P =.005) were predictors of SCI. History of cerebrovascular disease (9.6% vs 3.5%; P =.002), chronic obstructive pulmonary disease (9.5% vs 5.4%; P =.01), coronary artery disease (8.5% vs 5.3%; P =.03), smoking (8.9% vs 4.2%) and female gender (5.3% men vs 8.2% women; P =.05) were predictors of CVA. Subgroup analysis showed no significant difference between groups B and C (SCI, 6.3% vs 6.1%; CVA, 6.7% vs 6.1%). LSA revascularization was not protective for SCI (7.5% vs 4.1%; P =.3) or CVA (6.1% vs 6.4%; P =.9). Women who underwent revascularization had an increased incidence of CVA event compared with all other subgroups (group A: 5.6% men, 8.4% women, P =.16; group B: 6.6% men, 5.3% women, P =.9; group C: 2.8% men, 11.9% women, P =.03). Conclusions: LSA coverage does not appear to result in an increased incidence of SCI or CVA event when a strategy of selective revascularization is adopted. Selective LSA revascularization results in similar outcomes among the three cohorts studied. Revascularization in women carries an increased risk of a CVA event and should be reserved for select cases.

AB - Objective: This study assessed the risk of left subclavian artery (LSA) coverage and the role of revascularization in a large population of patients undergoing thoracic endovascular aortic aneurysm repair. Methods: A retrospective multicenter review of 1189 patient records from 2000 to 2010 was performed. Major adverse events evaluated included cerebrovascular accident (CVA) and spinal cord ischemia (SCI). Subgroup analysis was performed for noncovered LSA (group A), covered LSA (group B), and covered/revascularized LSA (group C). Results: Of 1189 patients, 394 had LSA coverage (33.1%), and 180 of these patients (46%) underwent LSA revascularization. In all patients, emergency operations (9.5% vs 4.3%; P =.001), renal failure (12.7% vs 5.3%; P =.001), hypertension (7% vs 2.3%; P =.01), and number of stents placed (1 = 3.7%, 2 = 7.4%, ≥3 = 10%; P =.005) were predictors of SCI. History of cerebrovascular disease (9.6% vs 3.5%; P =.002), chronic obstructive pulmonary disease (9.5% vs 5.4%; P =.01), coronary artery disease (8.5% vs 5.3%; P =.03), smoking (8.9% vs 4.2%) and female gender (5.3% men vs 8.2% women; P =.05) were predictors of CVA. Subgroup analysis showed no significant difference between groups B and C (SCI, 6.3% vs 6.1%; CVA, 6.7% vs 6.1%). LSA revascularization was not protective for SCI (7.5% vs 4.1%; P =.3) or CVA (6.1% vs 6.4%; P =.9). Women who underwent revascularization had an increased incidence of CVA event compared with all other subgroups (group A: 5.6% men, 8.4% women, P =.16; group B: 6.6% men, 5.3% women, P =.9; group C: 2.8% men, 11.9% women, P =.03). Conclusions: LSA coverage does not appear to result in an increased incidence of SCI or CVA event when a strategy of selective revascularization is adopted. Selective LSA revascularization results in similar outcomes among the three cohorts studied. Revascularization in women carries an increased risk of a CVA event and should be reserved for select cases.

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