Left hemispheric activation in depersonalization disorder: A case report

Eric Hollander, Jose L. Carrasco, Linda S. Mullen, Sari Trungold, Concetta M. DeCaria, James Towey

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29 Scopus citations

Abstract

Depersonalization disorder is classified in DSM-III-R (APA 1987) as a dissociative disorder characterized by altered perception or experience of the self. To date, there are no known reports of the neurobiological features of this disorder. We report clinical and biological correlates in a patient with depersonalization disorder previously unresponsive to a variety of anticonvulsant, monoamine oxidase inhibitor, and tricyclic antidepressant trials, but for whom fluoxetine partially reduced depersonalization symptoms, but not associated anxiety and depression. Neurophysiological, neuroanatomical and neuropsychological findings revealed left hemispheric frontal-temporal activation and decreased left caudate perfusion. These findings suggest a similarity to the neuropsychiatric data reported in obsessive-compulsive disorder patients.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalBiological Psychiatry
Volume31
Issue number11
DOIs
Publication statusPublished - Jun 1 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Hollander, E., Carrasco, J. L., Mullen, L. S., Trungold, S., DeCaria, C. M., & Towey, J. (1992). Left hemispheric activation in depersonalization disorder: A case report. Biological Psychiatry, 31(11), 1157-1162. https://doi.org/10.1016/0006-3223(92)90161-R