Left atrial appendage ligation and ablation for persistent atrial fibrillation: The LAALA-AF registry

Dhanunjaya Lakkireddy, Arun Sridhar Mahankali, Arun Kanmanthareddy, Randall Lee, Nitish Badhwar, Krzysztof Bartus, Donita Atkins, Sudharani Bommana, Jie Cheng, Abdi Rasekh, Luigi Di Biase, Andrea Natale, Jayant Nath, Ryan Ferrell, Matthew Earnest, Yeruva Madhu Reddy

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Objectives This study was intended to evaluate the impact of adding the left atrial appendage (LAA) closure system (LARIAT) procedure to conventional atrial fibrillation (AF) ablation in patients with persistent AF. Background Percutaneous endoepicardial LARIAT may result in both mechanical and electrical exclusion of the LAA and aid in improving the outcomes of catheter ablation by eradicating the LAA triggers and altering the substrate. Methods We performed a prospective observational study of patients with persistent AF referred for AF ablation. Patients underwent LAA ligation with LARIAT procedure before undergoing AF ablation (LARIAT group). Age- and sex-matched persistent AF patients undergoing AF ablation during the same time frame were included in the control group (ablation-only group). Results A total of 138 patients were included in the study, with 69 patients in the LARIAT group. The mean age of the population was 67 ± 10 years, with 96 (70%) men. Left atrial (LA) size, CHADS2, CHADSVasc, and HAS-BLED scores were higher in the LARIAT group when compared with the ablation-only group. There were no differences in the type of lesions during AF ablation between the groups. The primary outcome of freedom from AF at 1 year off antiarrhythmic therapy after 1 ablation procedure was higher in the LARIAT group (45 [65%] vs. 27 [39%]; p = 0.002). More patients in the ablation-only group underwent repeat ablation because of AF recurrence (11 [16%] vs. 23 [33%]; p = 0.018). Conclusions In patients with persistent AF, addition of LAA ligation with the LARIAT device to conventional ablation appears to improve the success rate of AF ablation.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalJACC: Clinical Electrophysiology
Issue number3
StatePublished - Jun 2015
Externally publishedYes


  • atrium
  • catheter ablation
  • fibrillation
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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