Left Atrial Appendage Isolation in Patients With Longstanding Persistent AF Undergoing Catheter Ablation: BELIEF Trial

Luigi Di Biase, J. David Burkhardt, Prasant Mohanty, Sanghamitra Mohanty, Javier E. Sanchez, Chintan Trivedi, Mahmut Güneş, Yalçın Gökoğlan, Carola Gianni, Rodney P. Horton, Sakis Themistoclakis, G. Joseph Gallinghouse, Shane Bailey, Jason D. Zagrodzky, Richard H. Hongo, Salwa Beheiry, Pasquale Santangeli, Michela Casella, Antonio Dello Russo, Amin Al-AhmadPatrick Hranitzky, Dhanunjaya Lakkireddy, Claudio Tondo, Andrea Natale

Research output: Contribution to journalArticlepeer-review

253 Scopus citations


Background Longstanding persistent (LSP) atrial fibrillation (AF) is the most challenging type of AF. In addition to pulmonary vein isolation, substrate modification and triggers ablation have been reported to improve freedom from AF in patients with LSPAF. Objectives This study sought to assess whether the empirical electrical isolation of the left atrial appendage (LAA) could improve success at follow-up. Methods This was an open-label, randomized study assessing the effectiveness of empirical electrical left atrial appendage isolation for the treatment of LSPAF. Patients were randomly assigned to undergo empirical electrical left atrial appendage isolation along with extensive ablation (group 1; n = 85) or extensive ablation alone (group 2; n = 88). Recurrence of atrial arrhythmias was the primary endpoint. Secondary endpoints included cardiac-related hospitalization, all-cause mortality, and stroke at follow-up. Results Major clinical characteristics were not different between the 2 groups. At 12-month follow-up, 48 (56%) patients in group 1 and 25 (28%) in group 2 were recurrence free after a single procedure (unadjusted hazard ratio [HR] for recurrence with standard ablation: 1.92; 95% confidence interval [CI]: 1.3 to 2.9; log-rank p = 0.001). After adjusting for age, sex, and left atrial size, standard ablation was predictive of recurrence (HR: 2.22; 95% CI: 1.29 to 3.81; p = 0.004). During repeat procedures, empirical electrical left atrial appendage isolation was performed in all patients. After an average of 1.3 procedures, cumulative success at 24-month follow-up was reported in 65 (76%) in group 1 and in 49 (56%) in group 2 (unadjusted HR: 2.24; 95% CI: 1.3 to 3.8; log-rank p = 0.003). Conclusions This randomized study showed that both after a single procedure and after redo procedures in patients with LSPAF, empirical electrical isolation of the LAA improved long-term freedom from atrial arrhythmias without increasing complications. (Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Longstanding Persistent Atrial Fibrillation Undergoing Catheter Ablation [BELIEF]; NCT01362738)

Original languageEnglish (US)
Pages (from-to)1929-1940
Number of pages12
JournalJournal of the American College of Cardiology
Issue number18
StatePublished - Nov 1 2016


  • arrhythmia
  • atrial fibrillation
  • non-PV trigger
  • pulmonary vein
  • radiofrequency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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