Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct

Peifu Jiao, Hongyu Zhou, Mario Otto, Qingxin Mu, Liwen Li, Gaoxing Su, Yi Zhang, Elizabeth R. Butch, Scott E. Snyder, Guibin Jiang, Bing Yan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

To conquer complex and devastating diseases such as cancer, more coordinated and combined attack strategies are needed. We suggest that these can be beautifully achieved by using nanoconstruct design. We present an example showing that neuroblastoma cells are selectively killed by a nanoconstruct that specifically targets neuroblastoma cells, pushes cells to the vulnerable phase of the cell cycle, and greatly enhances radiation-induced cell death. The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule.

Original languageEnglish (US)
Pages (from-to)13918-13921
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number35
DOIs
StatePublished - Sep 7 2011
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Jiao, P., Zhou, H., Otto, M., Mu, Q., Li, L., Su, G., Zhang, Y., Butch, E. R., Snyder, S. E., Jiang, G., & Yan, B. (2011). Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct. Journal of the American Chemical Society, 133(35), 13918-13921. https://doi.org/10.1021/ja206118a