TY - JOUR
T1 - Lawsone (2-OH-1,4-naphthoquinone) derived from the henna plant increases the oxygen affinity of sickle cell blood
AU - Chang, Henry
AU - Suzuka, Sandra Ewert
PY - 1982/7/30
Y1 - 1982/7/30
N2 - We examined an extract of the henna plant for the ability to inhibit the sickling of hemoglobin S-containing red cells upon deoxygenation invitro and found that it could do so. Further investigation revealed that the active principle was lawsone, 2-OH-1,4-naphthoquinone, which produced an increase in the oxygen affinity of SS blood at levels as low as 1 mM of the compound but with little change in the characteristics of normal blood at this concentration.
AB - We examined an extract of the henna plant for the ability to inhibit the sickling of hemoglobin S-containing red cells upon deoxygenation invitro and found that it could do so. Further investigation revealed that the active principle was lawsone, 2-OH-1,4-naphthoquinone, which produced an increase in the oxygen affinity of SS blood at levels as low as 1 mM of the compound but with little change in the characteristics of normal blood at this concentration.
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U2 - 10.1016/0006-291X(82)91534-0
DO - 10.1016/0006-291X(82)91534-0
M3 - Article
C2 - 7126231
AN - SCOPUS:0020362527
SN - 0006-291X
VL - 107
SP - 602
EP - 608
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -