Lawsone (2-OH-1,4-naphthoquinone) derived from the henna plant increases the oxygen affinity of sickle cell blood

Henry Chang, Sandra Ewert Suzuka

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We examined an extract of the henna plant for the ability to inhibit the sickling of hemoglobin S-containing red cells upon deoxygenation invitro and found that it could do so. Further investigation revealed that the active principle was lawsone, 2-OH-1,4-naphthoquinone, which produced an increase in the oxygen affinity of SS blood at levels as low as 1 mM of the compound but with little change in the characteristics of normal blood at this concentration.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume107
Issue number2
DOIs
StatePublished - Jul 30 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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