We examined an extract of the henna plant for the ability to inhibit the sickling of hemoglobin S-containing red cells upon deoxygenation invitro and found that it could do so. Further investigation revealed that the active principle was lawsone, 2-OH-1,4-naphthoquinone, which produced an increase in the oxygen affinity of SS blood at levels as low as 1 mM of the compound but with little change in the characteristics of normal blood at this concentration.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jul 30 1982|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology