@article{041cbb3bca534cfc80d00a0c8d62da6b,
title = "LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA",
abstract = "Lathyrism, a form of motoneurone disease induced by excessive consumption of the legume Lathyrus sativus (chickling pea), presents as signs of pyramidal tract involvement. Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume. BOAA, a potent agonist of the excitatory neurotransmitter glutamate, is likely to be causally associated with lathyrism in man.",
author = "Spencer, {Peter S.} and Albert Ludolph and Dwivedi, {M. P.} and Roy, {Dwijendra N.} and Jacques Hugon and Schaumburg, {H. H.}",
note = "Funding Information: We thank Dr R. C. Agrawal, Prof K. Ahmad, Dr D. Cohn, Dr M. Das, Dr A. Haque, Dr A. Hirano, Dr S. Huddar, Prof N. Islam, Dr A. Kaul, Dr A. Korcyn, Dr A. M. Md. Hossain, Prof M. A. Mannan, Dr G. D. Mohammad, Dr P. Nunn, and Dr S. P. Singh for their assistance and discussion, Mr R. Robertson and Mrs L. Galietti for technical help, and Mrs V. Palmer for videotaping subjects. We also thank the following institutions for their cooperation-Industrial Toxicology Research Centre, Lucknow, and Occupational Health Centre, Kanpur, India, Institution of Food Sciences, Dhaka, Bangladesh, Postgraduate Medical Research Institute, Dhaka, Bangladesh, Rewa Medical College, Rewa, India, Swedish Free Church Aid Lathyrism Project, Dhaka and Rajshahi, Bangladesh. The work was supported by NIH grant NS 19611 and by grants from the Amyotrophic Lateral Sclerosis Society of America, Ford Foundation, Dhaka, Muscular Dystrophy Foundation, New York, Third World Medical Research Foundation, Inc, New York, Deutsche Forschungsgemeinschaft, FRG, and Fondation pour la Recherche Medicale, France. Correspondence should be addressed to P. S. Neurotoxicology, Albert Einstein College of Medicine, Avenue, Bronx, New York 10461, USA.",
year = "1986",
month = nov,
day = "8",
doi = "10.1016/S0140-6736(86)90468-X",
language = "English (US)",
volume = "328",
pages = "1066--1067",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8515",
}